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Review
Plants frequently have to weather both biotic and abiotic stressors, and have evolved sophisticated adaptation and defense mechanisms. In recent years, chromatin modifications, nucleosome positioning, and DNA ...
Genome Biology 2017 18:124
Published on: 27 June 2017
Method
Single-cell RNA-seq (scRNA-seq) provides a comprehensive measurement of stochasticity in transcription, but the limitations of the technology have prevented its application to dissect variability in RNA proces...
Genome Biology 2017 18:123
Published on: 27 June 2017
Research
Paradoxically, centromeres are known both for their characteristic repeat sequences (satellite DNA) and for being epigenetically defined. Maize (Zea mays mays) is an attractive model for studying centromere posit...
Genome Biology 2017 18:121
Published on: 21 June 2017
Research Highlight
A distinct chromatin mark, H3K36me3, has been found to engage in temperature-dependent alternative splicing and ambient temperature-dependent flowering-time control in Arabidopsis.
Genome Biology 2017 18:119
Published on: 19 June 2017
Research Highlight
Epigenetic profiling in diploid, allopolyploid, and domesticated cotton shows that despite most DNA methylation being conserved and stably inherited, alterations likely due to hybridization and domestication a...
Genome Biology 2017 18:117
Published on: 19 June 2017
Research Highlight
Fine-mapping to identify causal variants in genome-wide association studies remains challenging. A recent study provides guidance for future research.
Genome Biology 2017 18:118
Published on: 19 June 2017
Review
Studies on genetic–epigenetic interactions, including the mapping of methylation quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation (hap-ASM), have become a major focus in ...
Genome Biology 2017 18:120
Published on: 19 June 2017
Research
The daily gene expression oscillations that underlie mammalian circadian rhythms show striking differences between tissues and involve post-transcriptional regulation. Both aspects remain poorly understood. We...
Genome Biology 2017 18:116
Published on: 16 June 2017
Research
Post-transcriptional regulation of gene expression can be achieved through the control of mRNA stability, cytoplasmic compartmentalization, 3′ UTR length and translational efficacy. Spermiogenesis, a process t...
Genome Biology 2017 18:105
Published on: 15 June 2017
Research
The genetic relationships reported by recent studies between Sherpas and Tibetans are controversial. To gain insights into the population history and the genetic basis of high-altitude adaptation of the two gr...
Genome Biology 2017 18:115
Published on: 15 June 2017
Research
Plant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. Whilst much is known on the signaling components mediating diurnal, light, and tem...
Genome Biology 2017 18:114
Published on: 15 June 2017
Correspondence
While the analysis of Bornelöv et al. is informative, they provide evidence for the existence of only 3% of the reported avian missing genes set, and thus do not significantly challenge our main findings that ...
Genome Biology 2017 18:113
Published on: 14 June 2017
Research Highlight
Epigenetic clocks provide powerful tools to evaluate nutritional, hormonal, and genetic effects on aging. What can we learn from differences between species in how these clocks tick?
Genome Biology 2017 18:107
Published on: 14 June 2017
Research Highlight
A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new infor...
Genome Biology 2017 18:109
Published on: 14 June 2017
Correspondence
Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that hav...
Genome Biology 2017 18:112
Published on: 14 June 2017
Method
CRISPR is widely used to disrupt gene function by inducing small insertions and deletions. Here, we show that some single-guide RNAs (sgRNAs) can induce exon skipping or large genomic deletions that delete exo...
Genome Biology 2017 18:108
Published on: 14 June 2017
Research
The Parsis are one of the smallest religious communities in the world. To understand the population structure and demographic history of this group in detail, we analyzed Indian and Pakistani Parsi populations...
Genome Biology 2017 18:110
Published on: 14 June 2017
Research
The functional divergence of duplicate genes (ohnologues) retained from whole genome duplication (WGD) is thought to promote evolutionary diversification. However, species radiation and phenotypic diversificat...
Genome Biology 2017 18:111
Published on: 14 June 2017
Research
The organisation of vertebrate genomes into topologically associating domains (TADs) is believed to facilitate the regulation of the genes located within them. A remaining question is whether TAD organisation ...
Genome Biology 2017 18:106
Published on: 14 June 2017
Research
Long-term evolution of sex chromosomes is a dynamic process shaped by gene gain and gene loss. Sex chromosome gene traffic has been studied in XY and ZW systems but no detailed analyses have been carried out f...
Genome Biology 2017 18:104
Published on: 8 June 2017
Research
Global warming severely affects flowering time and reproductive success of plants. Alternative splicing of pre-messenger RNA (mRNA) is an important mechanism underlying ambient temperature-controlled responses...
Genome Biology 2017 18:102
Published on: 1 June 2017
Research
Polyploidy is a pervasive evolutionary feature of all flowering plants and some animals, leading to genetic and epigenetic changes that affect gene expression and morphology. DNA methylation changes can produc...
Genome Biology 2017 18:99
Published on: 31 May 2017
Research
The chromodomain helicase DNA-binding family of ATP-dependent chromatin remodeling factors play essential roles during eukaryote growth and development. They are recruited by specific transcription factors and...
Genome Biology 2017 18:103
Published on: 31 May 2017
Software
Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial genome engineering. We describe Millstone, a...
Genome Biology 2017 18:101
Published on: 25 May 2017
Method
We present a method for identifying genomic modifications that optimize a complex phenotype through multiplex genome engineering and predictive modeling. We apply our method to identify six single nucleotide m...
Genome Biology 2017 18:100
Published on: 25 May 2017
Impact Factor: 11.908
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