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A meeting report of the sessions on human, eukaryotic and bacterial genome sequencing at the American Society for Microbiology and Institut Pasteur joint conference: Genomes 2000 International Conference on Mi...
A report from the Genome Biology session of the 4th annual conference on microbial genomes, Virginia, February 12-15, 2000.
A report from the second Annual Cardiovascular Genomics Meeting, Sponsored by Cambridge Healthtech, Inc., Miami, January 31-February 1, 2000.
A report from the Keystone Protein kinase C: structure, regulation and cellular function meeting, New Mexico, February 5-10, 2000.
A report of work on the structure and function of the nuclear envelope and nuclear pores, presented at the 39th annual meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999.
Living cells organize their internal contents by coordinating the chaotic thermal motion of protein molecules. A recent study, combining experiment with stochastic simulation, shows how this might be achieved ...
Recent sequence and cytogenetic analyses of heterochromatin in Arabidopsis, together with other results from Arabidopsis and maize, indicate that plant heterochromatin can have very different origins, composition...
Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems.
The characterization of complex cellular responses to diverse stimuli can be studied by the use of emerging chip-based technologies.
Proteins of the Rab and SNARE families target vesicles to their intracellular destinations. A comparison of these families from the budding yeast, fission yeast, nematode and fruitfly genomes has implications ...
Genomic sequencing of the Toll-like receptor 4 gene in humans, mice, chimpanzee and baboon has shown that the Tlr4 protein is polymorphic.
Clever use of a mutation that allows tetrad analysis in a higher plant has enabled researchers to map the centromeres of Arabidopsis genetically with high precision.
The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individua...
On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional grou...
The use of cDNA arrays has allowed monitoring of the change in expression of host cell genes during HIV-1 infection.
Error-free protein plus nucleic acid libraries have been generated by fusing mRNA to expressed protein and selecting for full-length proteins.
Genome-wide yeast two-hybrid screening has provided a census of protein-protein interactions in Saccharomyces cerevisiae.
DNA microarray analysis has been used for the first time to define clinically relevant subtypes of lymphoma.
Information about the set of amino-acid sequences that will fold to a given target protein structure can be predicted without assuming complete knowledge of the possible conformational space they can occupy.
The nucleotide sequence of the 120 megabase euchromatic region of the Drosophila melanogaster genome is reported.
Transcriptional analysis has been used to probe the biology of mycobacterial responses to antibiotics and to suggest new drug targets.
Expression patterns of Vibrio cholerae virulence genes determined during an infection differ dramatically from those observed in conventional in vitro analyses.
A new technique for the selection of newly synthesized DNA has enabled the selection and amplification of putative origins of replication on the human X chromosome.
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