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Hopping along DNA

Genome Biology20001:spotlight-20000713-02

https://doi.org/10.1186/gb-spotlight-20000713-02

  • Published:

Keywords

  • Oxidative Damage
  • Adenine
  • Guanine
  • Charge Recombination
  • Hole Transport

Oxidative damage yields isolated electrons and their corresponding 'holes' that can migrate along DNA. In the 6 July Nature Lewis et al. determine rate constants of ~5x107 s-1 and 5x106 s-1, respectively, for forward and return hole transport from a single guanine base to a double guanine base across a single adenine (Nature 2000, 406:51-53). These rates mean that electrons do not linger long enough to participate in strand-cleavage reactions. But the electrons move too slowly to avoid charge recombination, so DNA cannot act as a useful molecular wire.

References

  1. Distance-dependent electron transfer in DNA hairpins.Google Scholar
  2. Nature, [http://www.nature.com/nature/]

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