Skip to main content
  • Research news
  • Published:

Hopping along DNA

Oxidative damage yields isolated electrons and their corresponding 'holes' that can migrate along DNA. In the 6 July Nature Lewis et al. determine rate constants of ~5x107 s-1 and 5x106 s-1, respectively, for forward and return hole transport from a single guanine base to a double guanine base across a single adenine (Nature 2000, 406:51-53). These rates mean that electrons do not linger long enough to participate in strand-cleavage reactions. But the electrons move too slowly to avoid charge recombination, so DNA cannot act as a useful molecular wire.


  1. Distance-dependent electron transfer in DNA hairpins.

  2. Nature, []

Download references


Rights and permissions

Reprints and permissions

About this article

Cite this article

Wells, W. Hopping along DNA. Genome Biol 1, spotlight-20000713-02 (2000).

Download citation

  • Published:

  • DOI: