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Hopping along DNA

Oxidative damage yields isolated electrons and their corresponding 'holes' that can migrate along DNA. In the 6 July Nature Lewis et al. determine rate constants of ~5x107 s-1 and 5x106 s-1, respectively, for forward and return hole transport from a single guanine base to a double guanine base across a single adenine (Nature 2000, 406:51-53). These rates mean that electrons do not linger long enough to participate in strand-cleavage reactions. But the electrons move too slowly to avoid charge recombination, so DNA cannot act as a useful molecular wire.


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    Distance-dependent electron transfer in DNA hairpins.

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Wells, W. Hopping along DNA. Genome Biol 1, spotlight-20000713-02 (2000).

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  • Oxidative Damage
  • Adenine
  • Guanine
  • Charge Recombination
  • Hole Transport