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Breast cancer linked to chromatin remodeling

Genome Biology20001:spotlight-20000731-01

https://doi.org/10.1186/gb-spotlight-20000731-01

  • Published:

Keywords

  • Breast Cancer
  • Ovarian Cancer
  • Human Cell
  • Close Inspection
  • Chromatin Remodel

BRCA1 is a tumor-suppressor gene linked to familial breast and ovarian cancers. In the July 21 Cell, Bochar et al. find that the predominant BRCA1-containing complex in human cells is the SWI/SNF-related chromatin remodeling complex (Cell 2000, 102:257-265). This may explain the multitude of properties that have been ascribed to BRCA1, including effects on transcription, DNA repair, and cell-cycle checkpoints. Mutations in SNF5, another subunit of the SWI/SNF complex, have been shown to result in aggressive pediatric cancer, and a close inspection of other SWI/SNF proteins and genes may turn up other cancer culprits.

References

  1. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.Google Scholar
  2. Cell, [http://www.cell.com/]
  3. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.Google Scholar

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