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Much of our knowledge about the mechanisms of vertebrate early development comes from studies using Xenopus laevis. The recent development of a remarkably efficient method for generating transgenic embryos is now...
The genome of Mycobacterium tuberculosis H37Rv has five copies of a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 (lhp) and ESAT-6 (esat-6) gene families (encoding secret...
A 'protein chip' incorporating most of the yeast proteome can be used for the high-throughput characterization of proteins.
The Human Alternative Splicing DataBase (HASDB) contains information about many of the alternative splicing events that have so far been identified in humans.
The Mouse SNP Database website contains a searchable depository of mouse single-nucleotide polymorphisms (SNPs).
The Universal Mutation Database (UMD) was developed to allow researchers interested in particular human disease genes to query gene-specific databases for mutational information in a dynamic and interactive fa...
Metal ions are essential nutrients, yet they can also be toxic if they over-accumulate. Homeostatic mechanisms and detoxification systems therefore precisely control their intracellular levels and distribution...
Analysis of the human genome draft sequences has revealed a more complete portrait of the olfactory receptor gene repertoire in humans than was available previously. The new information provides a basis for de...
A report on the thirteenth international Caenorhabditis elegans meeting, University of California, Los Angeles, USA, 22-26 June 2001.
The ubiquitin-dependent protein degradation pathway is essential for the proteolysis of intracellular proteins and peptides. Deubiquitinating enzymes constitute a complex protein family involved in a multitude...
Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the mechanism of action of flavopiridol as a...
An unusual genetic system has allowed recombination to be recognized in an animal mitochondrial genome.
Gene sequence conservation and lineage-specific evolution are revealed by analysis of homologous sequences in human and mouse.
A DNA array has been used to measure the affinity of wild-type and mutant variants of a zinc-finger-protein DNA-binding domain for all combinations of its binding site on DNA.
Nuclear pore complexes, the conduits for information exchange between the nucleus and cytoplasm, appear broadly similar in eukaryotes from yeast to human. Precisely how nuclear pore complexes regulate macromol...
SP100 is a nuclear protein that displays a number of alternative splice variants. In Old World monkeys, apes and humans one of these variants is extended by a retroprocessed pseudogene, HMG1L3, whose antecedent g...
Genetic screens in Drosophila have provided a wealth of information about a variety of cellular and developmental processes. It is now possible to screen for mutant phenotypes in virtually any cell at any stage o...
Ribosomal proteins are encoded in all genomes of cellular life forms and are, generally, well conserved during evolution. In prokaryotes, the genes for most ribosomal proteins are clustered in several highly c...
Have nutritional constraints been involved in protein evolution?.
A report on the tenth Annual Bioinformatics and Genome Research meeting of the Cambridge Healthtech Institute's Beyond Genome 2001 series, San Francisco, USA, 17-19 June 2001.
The Biomolecular Interaction Network Database (BIND) was developed to undertake the mammoth task of providing a public database of all known biomolecular interactions.
The Arabidopsis Information Resource (TAIR) provides a collection of tools, links and news for researchers working with Arabidopsis thaliana.
A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap appr...
The Erratum to this article has been published in Genome Biology 2002 3:interactions2001.1
WT1 and SOX9 are transcription factors with critical roles in mammalian sex determination and gonadal development. Recent studies in vivo clarify the roles of two alternative splice isoforms of WT1, and demonstra...
Taking each coding sequence from the human genome in turn and identifying the subcellular localization of the corresponding protein would be a significant contribution to understanding the function of each of ...
It has recently been shown that the detection of gene fusion events across genomes can be used for predicting functional associations of proteins, including physical interaction or complex formation. To obtain...
A report on the Frontiers in Reproduction Symposium 2001 'Reproductive genetics, genomics and proteomics: advances in genetic, molecular and bioinformatics techniques', Cambridge, USA, 30 June to 1 July, 2001.
Conserved domains in proteins have crucial roles in protein interactions, DNA binding, enzyme activity and other important cellular processes. It will be of interest to determine the proportions of genes conta...
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