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A report on work presented at the 39th Annual Meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999
A report on work with small-molecule inhibitors of cellular processes presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define...
The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusion...
Serial analysis of gene expression (SAGE) has been used to analyze the complete human 'transcriptome' - the number, identity and level of expression of genes in humans.
Members of the Arabidopsis Genome Initiative, primarily from The Institute for Genomic Research, have completed sequencing one of the first two plant chromosomes.
Systems analysis of the complete genome sequence combined with biochemical information on metabolic pathways has been used to define and elucidate the relationship between genotype and phenotype for Haemophilus i...
Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that resistance to LPS is caused by defects in the Toll-lik...
The formin family of proteins has been implicated in signaling pathways of cellular morphogenesis in both animals and fungi; in the latter case, at least, they participate in communication between the actin cy...
The use of cDNA microarrays for the study and mapping of gene amplifications and deletions on a whole-genome scale provides a comparison of DNA copy numbers in normal and tumor cells at unprecedented resolution.
The PROCRUSTES server provides a method for determining protein-coding sequences in genomic DNA.
The particular interest of David Ussery and his group is in creating 'structural atlases' of genomes from a detailed analysis of variations in DNA structure.
For those experienced in statistical genetics and genetic mapping this is an excellent resource.
For those interested in DT40, a chick pre-B-cell line proving increasingly popular for use in gene targeting projects, this is a very useful site.
Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegansand humans.
The GENSCAN program is designed to predict complete gene structures, including exons, introns, promoter and polyadenylation signals, in genomic sequences.
Data are collected from Nature, Science, Cell, and Nature Cell Biologyto form a database and resource for the signaling pathways of human cells.
DIP is intended to help those studying protein-protein interactions, signaling pathways, multiple interactions and complex systems.
The signaling pathway database is an integrated database that links signal transduction systems to genetic information.
A wealth of resources related to the genetics and biology of the mouse can be accessed via this site.
Publicly available nucleotide sequences, along with their associated annotations are available here.
The Genome Database is the official central repository for mapping data from the International Human Genome Initiative.
This online version of a US Department of Energy publication provides detailed background information about the human genome project.
This online publication deals with the ethical, social and legal issues raised by genetic mapping and research.
This site has a collection of features dealing with different areas of genetic research, and is an interesting and useful piece of 'popular science'.
The primary resource for the zebrafish community is a vast site, and is also a jumping-off point to other relatively large zebrafish websites.
Developmental biology, primarily work with the embryos of Xenopus species X. laevis and X. tropicalis, is the focus of this site.
The puffer fish Fugu rubripes is perhaps better known as a Japanese delicacy, but its gene-rich, relatively small genome makes the puffer fish a suitable vertebrate for comparative mapping.
A comprehensive repertoire of tools available to attack fundamental biological problems is presented here.
Valuable information on the use of ribozymes as tools for the analysis of gene function can be found here.
This comprehensive online biology reference book consists of lists of terms covering an extensive range of biological topics, and is aimed primarily at graduate students.
A great site for anyone interested in breast cancer or mammary gland development - beginners and experienced researchers alike.
Providing a central scientific forum, run by scientists for scientists is the aim of this new and developing site, which shows a lot of potential.
A new, free-access part of Science's main website, devoted to career advice for junior scientists.
SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC mole...
This integrated immunogenetics database specializes in immunoglobulins, T-cell receptors and major histocompatibility complex (MHC) molecules.
The first publication of the genomic sequence of an entire human chromosome.
A novel Drosophila segment polarity gene is identified and shown to be required for release of Hedgehog protein from secreting cells.
The largest contiguous stretch of DNA yet sequenced in Drosophila suggests that fruit-flies have only half as many genes as Caenorhabditis elegans.
Plant defense responses are induced by recognition of a conserved epitope of the major protein of the bacterial flagellum. This could represent a general perception mechanism for plants to detect infection by ...
Bioinformatic analysis has been used to identify gene-fusion events in complete genomes and thus infer protein interactions on the basis of sequence analysis alone.
The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.
A genetic screen has identified genes controlling axonal dendrite development.
Can the selection by aminoacyl-tRNA synthetases for the correct tRNA substrate happen during binding? The results of equilibrium experiments suggest that it can.
An analysis of the set of all motifs and repeats found in all protein sequences.
Protein virulence factors can be secreted from bacterial cells using the machinery used to assemble the flagellum.
Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.
YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host de...
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