Skip to main content

Replicating both ways

Archeal DNA replication proteins are closely related to eukaryotic counterparts, but in the June 23 Science Myllykallio et al. report that the archeon Pyrococcus abyssi has a bacterial mode of replication (Science 2000, 288:2212-2215). Myllykallio et al. use the excess of G over C in the leading replication strand to identify a single origin of bi-directional replication in Pyrococcus. A comparison with a related archeon reveals that, as in bacteria, the replication terminus is a hotspot of genome shuffling. These two similarities with bacteria may be evidence for either convergent evolution or conservation of replication characteristics from the time of a common ancestor.


  1. Archaea and the origin(s) of DNA replication proteins.

  2. Science, []

Download references


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wells, W. Replicating both ways. Genome Biol 1, spotlight-20000629-02 (2000).

Download citation

  • Published:

  • DOI:


  • Common Ancestor
  • Convergent Evolution
  • Replication Protein
  • Genome Shuffling
  • Single Origin