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Open Access

Replicating both ways

  • William Wells
Genome Biology20001:spotlight-20000629-02

Published: 29 June 2000


Common AncestorConvergent EvolutionReplication ProteinGenome ShufflingSingle Origin

Archeal DNA replication proteins are closely related to eukaryotic counterparts, but in the June 23 Science Myllykallio et al. report that the archeon Pyrococcus abyssi has a bacterial mode of replication (Science 2000, 288:2212-2215). Myllykallio et al. use the excess of G over C in the leading replication strand to identify a single origin of bi-directional replication in Pyrococcus. A comparison with a related archeon reveals that, as in bacteria, the replication terminus is a hotspot of genome shuffling. These two similarities with bacteria may be evidence for either convergent evolution or conservation of replication characteristics from the time of a common ancestor.


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© BioMed Central Ltd 2000