- Research news
Watch out for aneuploidy
Genome Biology volume 1, Article number: spotlight-20000629-01 (2000)
In an analysis of both new and old microarray data in the July Nature Genetics, Hughes et al. find that results are frequently skewed by aneuploidy (Nat. Gen. 2000, 25:333-337). Their first clue was an unexpected transcript profile similarity between two unrelated yeast mutants; the cause turned out to be an extra copy of an entire chromosome. Approximately 8% of the yeast mutants examined had chromosome-wide expression biases, even though most of these mutants are not known to have chromosome transmission defects. In five cases a gained chromosome had a close homologue of the deleted gene, and in two cases a growth advantage was demonstrated.
Nature genetics, [http://www.nature.com/ng/]
About this article
Cite this article
Wells, W. Watch out for aneuploidy. Genome Biol 1, spotlight-20000629-01 (2000). https://doi.org/10.1186/gb-spotlight-20000629-01