Skip to main content
  • Research news
  • Published:

Targets for forkhead

Zhu et al. use the power of microarrays in the July 6 Nature to uncover the many targets of the yeast Forkhead (Fkh) proteins (Nature 2000, 406:90-94). On the basis of chromatin immunoprecipitation experiments, the regulation of transcription is either direct (confirmed for at least 4 of 33 co-regulated genes that are active during G2 and M cell cycle phases) or indirect (for a set of M/G1 genes). Aberrant regulation of two genes from the G2/M set, SWI5 and ACE2, apparently causes the aberrant regulation of the M/G1 set of genes. Koranda et al. show in an accompanying paper that Fkh works by mediating the binding of a positive regulator Ndd1 and an as yet unidentified negative regulator (Nature 2000, 406:94-98).


  1. Nature magazine, []

  2. Five years on the wings of fork head.

  3. NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae.

Download references


Rights and permissions

Reprints and permissions

About this article

Cite this article

Wells, W. Targets for forkhead. Genome Biol 1, spotlight-20000710-02 (2000).

Download citation

  • Published:

  • DOI: