Targets for forkhead

Zhu et al. use the power of microarrays in the July 6 Nature to uncover the many targets of the yeast Forkhead (Fkh) proteins (Nature 2000, 406:90-94). On the basis of chromatin immunoprecipitation experiments, the regulation of transcription is either direct (confirmed for at least 4 of 33 co-regulated genes that are active during G2 and M cell cycle phases) or indirect (for a set of M/G1 genes). Aberrant regulation of two genes from the G2/M set, SWI5 and ACE2, apparently causes the aberrant regulation of the M/G1 set of genes. Koranda et al. show in an accompanying paper that Fkh works by mediating the binding of a positive regulator Ndd1 and an as yet unidentified negative regulator (Nature 2000, 406:94-98).