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Targets for forkhead
Genome Biology volume 1, Article number: spotlight-20000710-02 (2000)
Zhu et al. use the power of microarrays in the July 6 Nature to uncover the many targets of the yeast Forkhead (Fkh) proteins (Nature 2000, 406:90-94). On the basis of chromatin immunoprecipitation experiments, the regulation of transcription is either direct (confirmed for at least 4 of 33 co-regulated genes that are active during G2 and M cell cycle phases) or indirect (for a set of M/G1 genes). Aberrant regulation of two genes from the G2/M set, SWI5 and ACE2, apparently causes the aberrant regulation of the M/G1 set of genes. Koranda et al. show in an accompanying paper that Fkh works by mediating the binding of a positive regulator Ndd1 and an as yet unidentified negative regulator (Nature 2000, 406:94-98).
Nature magazine, [http://www.nature.com/nature/]
Five years on the wings of fork head.
NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae.
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Wells, W. Targets for forkhead. Genome Biol 1, spotlight-20000710-02 (2000) doi:10.1186/gb-spotlight-20000710-02
- Cell Cycle
- Negative Regulator
- Positive Regulator
- Cycle Phase
- Chromatin Immunoprecipitation