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  4. Granzymes, a family of serine proteases, are expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells, components of the immune system that protect higher organisms against viral infectio...

    Authors: Joseph A Trapani
    Citation: Genome Biology 2001 2:reviews3014.1
    Content type: Protein family review Published on:

  5. All G-protein-coupled receptors (GPCRs) share a common molecular architecture (with seven putative transmembrane segments) and a common signaling mechanism, in that they interact with G proteins (heterotrimeri...

    Authors: Anthony J Harmar
    Citation: Genome Biology 2001 2:reviews3013.1
    Content type: Protein family review Published on:

  7. Gene-expression profiling has yielded important information about simple systems, but complex tissues have not yet been widely profiled. Four recent studies of mammalian skeletal muscles have added to the cata...

    Authors: Richard Hampson and Simon M Hughes
    Citation: Genome Biology 2001 2:reviews1033.1
    Content type: Minireview Published on:

  8. Symbioses between unicellular and multicellular organisms have contributed significantly to the evolution of life on Earth. As exemplified by several studies of bacterium-insect symbioses, modern genomic techn...

    Authors: Evelyn Zientz, Francisco J Silva and Roy Gross
    Citation: Genome Biology 2001 2:reviews1032.1
    Content type: Minireview Published on:

  10. Authors: Jonathan B Weitzman
    Citation: Genome Biology 2001 2:spotlight-20011121-01
    Content type: Research news Published on:

  11. A report on the International conference on Halophilic Microorganisms, Sevilla, Spain, 23-27 September 2001.

    Authors: Mike Dyall-Smith and Michael Danson
    Citation: Genome Biology 2001 2:reports4033.1
    Content type: Meeting report Published on:

  12. A report on the symposium 'Mycobacteria - new developments' at the 149th meeting of Society for General Microbiology, University of East Anglia, Norwich, UK, 10-13 September 2001.

    Authors: M Jo Colston
    Citation: Genome Biology 2001 2:reports4032.1
    Content type: Meeting report Published on:

  13. Affymetrix oligonucleotide arrays simultaneously measure the abundances of thousands of mRNAs in biological samples. Comparability of array results is necessary for the creation of large-scale gene expression ...

    Authors: Andrew A Hill, Eugene L Brown, Maryann Z Whitley, Greg Tucker-Kellogg, Craig P Hunter and Donna K Slonim
    Citation: Genome Biology 2001 2:research0055.1
    Content type: Research Published on:

  15. Detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. We developed and implemented a simple relative rates test in an attempt to assess the rate constancy...

    Authors: I King Jordan, Fyodor A Kondrashov, Igor B Rogozin, Roman L Tatusov, Yuri I Wolf and Eugene V Koonin
    Citation: Genome Biology 2001 2:research0053.1
    Content type: Research Published on:

  18. The biomedical community is rapidly developing new methods of data analysis for microarray experiments, with the goal of establishing new standards to objectively process the massive datasets produced from fun...

    Authors: David M Mutch, Alvin Berger, Robert Mansourian, Andreas Rytz and Matthew-Alan Roberts
    Citation: Genome Biology 2001 2:preprint0009.1
    Content type: Deposited research article Published on:

  21. A response to Evidence for symmetric chromosomal inversions around the replication origin in bacteria by JA Eisen, JF Heidelberg, O White, SL Salzberg. Genome Biology 2000, 1:research0011.1-0011.9.

    Authors: Paweł Mackiewicz, Dorota Mackiewicz, Maria Kowalczuk and Stanisław Cebrat
    Citation: Genome Biology 2001 2:interactions1004.1
    Content type: Correspondence Published on:

  25. A report on the 2001 Eukaryotic DNA Replication meeting, Cold Spring Harbor Laboratory, New York, 5-9 September 2001.

    Authors: Conrad A Nieduszynski, Anne D Donaldson and J zaJulian Blow
    Citation: Genome Biology 2001 2:reports4030.1
    Content type: Meeting report Published on:

  27. Sequestration of transcription factors in the membrane is emerging as an important mechanism for the regulation of gene expression. A handful of membrane-spanning transcription factors has been previously iden...

    Authors: Joel Zupicich, Steven E Brenner and William C Skarnes
    Citation: Genome Biology 2001 2:research0050.1
    Content type: Research Published on:

  29. Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by expe...

    Authors: Lakshminarayan M Iyer, L Aravind, Peer Bork, Kay Hofmann, Arcady R Mushegian, Igor B Zhulin and Eugene V Koonin
    Citation: Genome Biology 2001 2:research0051.1
    Content type: Research Published on:

  32. The BMERC website provides a platform for searching DNA, RNA and protein sequence databases and performing bioinformatic analyses.

    Authors: Vasudeva Ginjala
    Citation: Genome Biology 2001 2:reports2018
    Content type: Web report Published on:

  45. The effects of launch vibrations and microgravity on the cytoskeletal organization of a Jurkat leukemic cell line flown in space have been identified using a microarray approach.

    Authors: Agnieszka M Lichanska
    Citation: Genome Biology 2001 2:reports0043
    Content type: Paper report Published on:

  46. A new computational method for whole-genome analysis by in silico restriction mapping has been developed and has been evaluated by comparison with experimental restriction analysis of tumor DNA.

    Authors: Agnieszka M Lichanska
    Citation: Genome Biology 2001 2:reports0042
    Content type: Paper report Published on:

  47. A critical evaluation of the quality of different versions of the draft human genome sequence has revealed discrepancies between experimental mapping results and data available online.

    Authors: Reiner Veitia
    Citation: Genome Biology 2001 2:reports0041
    Content type: Paper report Published on:

  50. The Prostate Expression Database (PEDB) is an on-site database of expressed sequences from both normal and diseased prostate tissues, with an integrated suite of bioinformatics tools for analyzing gene express...

    Authors: Steven G Gray
    Citation: Genome Biology 2001 2:reports2015
    Content type: Web report Published on:

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Genome Biology

ISSN: 1474-760X

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