Skip to content


Open Access

Ancient introns

  • Jonathan B Weitzman
Genome Biology20012:spotlight-20011113-01

Published: 13 November 2001


Protein SequenceComputer ProgramHomologous GeneProtein DataModule Boundary

The origins of introns and their evolutionary role remain unclear. In the November 6 Proceedings of the National Academy of Science, Fedorov et al. describe the use of a computer program, called INTRONMAP to present evidence for the existence of ancient introns (Proc Natl Acad Sci USA 2001, 98:13177-13182). They used the program to map intron positions onto homologous genes encoding proteins for which the three-dimensional structure is known. They applied the program to 665 nonredundant protein sequences in the Protein Data Bank and mapped over 8,000 introns. The result was a correlation of phase-zero introns with module boundaries in proteins, corresponding to ancient conserved regions (ACR). There was no correlation for phase-one or phase-two positions, or for non-ACR proteins (which presumably represent 'modern' genes).


  1. What introns have to tell us: hierarchy in genome evolution.Google Scholar
  2. Proceedings of the National Academy of Science, []
  3. INTONMAP, []
  4. Protein Data Bank, []


© BioMed Central Ltd 2001