Fugugenome rough draft completed
© BioMed Central Ltd 2001
Published: 30 October 2001
Fugu rubripes - the Japanese puffer fish - is farmed in Japan for its flesh and is considered a great delicacy. But it is its 365 million base genome that the interests scientists of the Fugu Genome Sequencing Consortium.
The Fugugenome contains similar genes and regulatory sequences to the human genome, but has substantially less 'junk DNA' compared to the 3 billion bases that constitute the human genome. On 26 October 2001, at the 13th International Genome Sequencing and Analysis Conference, San Diego, California, Sydney Brenner and colleagues from the Fugu Genome Sequencing Consortium announced the completion of the Fugu genome sequencing project.
The consortium employed a whole-genome shotgun strategy to sequence the fish's genome. The DNA was fragmented into pieces small enough to sequence and then reassembled by a new computational algorithm, JAZZ, which had been developed at the US Department of Energy's Joint Genome Institute (JGI) in Walnut Creek, California.
According to Brenner this "will illuminate the human genome sequence and help us to understand it." Trevor Hawkins, Director of the JGI, said, "comparative genomics programs are key to understanding the biology of the human genome."
The Consortium intends to publish an initial analysis of the draft Fugu genome early in 2002.
- Brenner S, Elgar G, Sandford R, Macrae A, Venkatesh B, Aparicio S: Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome. Nature 1993, 366:265-268., [http://www.nature.com/]
- 13th International Genome Sequencing and Analysis Conference, [http://www.tigr.org/cet/gss/gsac/]
- Sydney Brenner's Autobiography, [http://www.biomedcentral.com/info/brenner.asp]
- JGI - Fugu Genome Project, [http://Fugu.jgi-psf.org]
- Institute of Molecular and Cell Biology - Fugu Genome Project, [http://www.fugu-sg.org]
- MRC UK HGMP -The Fugu Genomics project, [http://fugu.hgmp.mrc.ac.uk]
- Molecular Sciences Institute, Berkeley, California, [http://www.molsci.org/welcome.shtml]
- Institute for Systems Biology, Seattle, [http://www.systemsbiology.org/home.html]