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When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA...
A report on the Jackson Laboratory 'Genomics meets nanoscience' meeting, Bar Harbor, USA, 9-12 October 2001.
An erratum to The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis by AJ Furley. Genome Biology 2001, 2:reviews1026.1-1026.5
The original article was published in Genome Biology 2001 2:reviews1026.1
The fission yeast Schizosaccharomyces pombe has long been a model organism for studies of eukaryotic cells, winning renown especially for studies of the cell cycle. Now that its genome has been sequenced, S. pomb...
Genome sequence comparisons reveal that some sets of genes are in similar linkage groups in different organisms while other sets are dispersed. Are some linkage groups maintained by chance, or is there an adva...
A large-scale study of regulated gene expression has identified novel genes that may be involved in zebrafish embryonic development
A generic method for purifying protein complexes coupled with mass spectroscopic identification has enabled part of the network of interactions within the yeast proteome to be unraveled
Sites in DNA that bind regulatory proteins can be detected computationally in various ways. Pattern discovery methods analyze collections of genes suspected to be co-regulated on the evidence, for example, of ...
Concepts of orthology and paralogy are become increasingly important as whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is assumed to be conserved am...
Adenine deamination in double-stranded RNA by specific adenine deaminases efficiently blocks RNA interference in vitro
Restricting their intake of calories can further extend the lifespan of long-lived Ames dwarf mice
A report on the 'Pathogen-host cell interactions' minisymposium at the 41st Annual Meeting of the American Society for Cell Biology, Washington DC, USA, 8-12 December 2001.
The completed Arabidopsis genome seems to be of limited value as a model for maize genomics. In addition to the expansion of repetitive sequences in maize and the lack of genomic micro-colinearity, maize-specific...
Viral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identific...
Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these data remains an important challenge. A variety of tool...
For researchers interested in tumor suppressors, and in particular the p53 protein, this is a useful website; it includes a p53 database, an APC database and a p53 mutation-analysis database
Y.F. Leung's Functional Genomics website is a portal of up-to-date annotated links to databases, software, analysis materials and protocols for functional genomics, microarrays, bioinformatics, proteomics and ...
An expression study of prospective bacterial drug-transporter genes has extended the range of substrates known to be transported and has identified an ABC-family drug transporter in Gram-negative bacteria
A report on the 15th International Mouse Genome Conference, Edinburgh, UK, 21-24 October 2001.
Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously a...
The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as si...
Recent work has identified the elusive male (pollen) determinant that underlies self-incompatibility in Brassica (cabbage). The key pollen factor, recognized by the stigma of an incompatible plant, is a small cys...
During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in var...
Microarray technologies are emerging as a promising tool for genomic studies. The challenge now is how to analyze the resulting large amounts of data. Clustering techniques have been widely applied in analyzin...
Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteri...
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