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Proteomic early detection of ovarian cancer
Genome Biologyvolume 3, Article number: spotlight-20020213-01 (2002)
Over 80% of ovarian cancers are diagnosed when the disease is at a late stage, with a consequent five-year survival rate of only around 35%. New technologies for the detection of early-stage ovarian cancer would therefore be of great benefit. In February 8 online edition of The Lancet, Emanuel Petricoin III and colleagues from the US Food and Drug Administration, Bethesda, show that computer-assisted detection of proteomic patterns could help in screening for ovarian cancer.
Petricoin et al. analysed blood proteins of women with ovarian cancer using mass spectroscopy and a novel computer-searching algorithm. They found a discriminatory proteomic pattern that correctly identified all 50 ovarian cancer cases and 63 of the 66 non-cancer cases from a set of 116 masked serum samples (sensitivity 100%; specificity 95%; positive predictive value 94%; Lancet 2002, 359:572-577).
"These findings justify a prospective population-based assessment of proteomic pattern technology, as a screening tool for all stages of ovarian cancer in high-risk and general populations," commented Emanuel Petricoin III.