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Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: α-synuclein, β-synuclein, and γ-synuclein. All synucleins have in co...
Non-viable granulosa cells recovered post-mortem from a mouflon sheep have been used to clone the dead animal using a domestic sheep as a surrogate oocyte donor and mother
Gene-expression profiling can distinguish the anatomical origin of over 90% of samples of ten different types of solid cancer
A new method for identifying the active site of an enzyme from structural information alone
Binding sites for the anti-tumor drug bizelesin in DNA are identified by in silico and in vitro analysis of AT-rich islands
The use of DNA sequences to estimate the timing of evolutionary events is increasingly popular, although it is fraught with practical difficulties. But the exponential growth of relevant information and improv...
With the large influx of raw sequence data from genome sequencing projects, there is a need for reliable automatic methods for protein sequence analysis and classification. The most useful tools use various me...
The complete assignment of the protein-coding regions of the human genome is a major challenge for genome biology today. We have already isolated many hitherto unknown full-length cDNAs as orthologs of unident...
Analysis of the regulation of the yeast cell cycle by nine cell-cycle transcriptional activators
In silico searches of promoter sequence motifs, combined with analysis of microarray data, have revealed potential synergistic interactions within the yeast transcriptional regulatory network
Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. P...
Affymetrix microarrays have become increasingly popular in gene-expression studies; however, limitations of the technology have not been well established for commercially available arrays. The hybridization si...
Tryptophan synthase consists of two subunits, α and β. Two distinct subgroups of β chain exist. The major group (TrpEb_1) includes the well-studied β chain of Salmonella typhimurium. The minor group of β chain (T...
A report on the 19th Whitehead Institute Symposium, Cambridge, USA, 14-16 October 2001.
A report on the fourth International Meeting on Single Nucleotide Polymorphisms and Complex Genome Analysis, Stockholm, Sweden, 10-13 October 2001.
The eukaryotic ubiquitin-conjugation system sets the turnover rate of many proteins and includes activating enzymes (E1s), conjugating enzymes (UBCs/E2s), and ubiquitin-protein ligases (E3s), which are respons...
A report on the Pseudomonas 2001 Meeting, Brussels, Belgium, 17-21 September 2001.
The homologous genes Spin (spindlin) and Ssty were first identified as genes involved in gametogenesis and seem to occur in multiple copies in vertebrate genomes. The mouse spindlin (Spin) protein was reported to...
In the post-genomic era newly sequenced genomes can be used to deduce organismal functions from our knowledge of other systems. Here we apply this approach to analyzing the aquaporin gene family in Arabidopsis th...
High-density oligonucleotide microarrays provide a powerful tool for assessing differential mRNA expression levels. Characterizing the noise resulting from the enzymatic and hybridization steps, called type I ...
A large family of G-protein-coupled receptors, with sequence homology to the oncoprotein MAS1, has been shown to be specifically expressed in nociceptive sensory neurons.
Predicted extracellular proteins of Bacillus subtilis have been compared with the experimental identification of the extracellular proteome by two-dimensional gel electrophoresis, peptide sequencing and mass spec...
Transcriptional profiling of 60 human cancer lines has been used to assess chemosensitivity to 232 chemical compounds.
Genetic evidence supports the recognition and conservation management of African forest and savannah elephants as two distinct species.
Systematic examination of the gene encoding CYP2B6, a human cytochrome P450, has characterized genetic polymorphisms that might account for its variability in expression and function between individuals.
Granzymes, a family of serine proteases, are expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells, components of the immune system that protect higher organisms against viral infectio...
All G-protein-coupled receptors (GPCRs) share a common molecular architecture (with seven putative transmembrane segments) and a common signaling mechanism, in that they interact with G proteins (heterotrimeri...
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