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A report on the Frontiers in Reproduction Symposium 2001 'Reproductive genetics, genomics and proteomics: advances in genetic, molecular and bioinformatics techniques', Cambridge, USA, 30 June to 1 July, 2001.
Conserved domains in proteins have crucial roles in protein interactions, DNA binding, enzyme activity and other important cellular processes. It will be of interest to determine the proportions of genes conta...
The reovirus λ2 protein catalyzes mRNA capping, that is, addition of a guanosine to the 5' end of each transcript in a 5'-to-5' orientation, as well as transfer of a methyl group from S-adenosyl-L-methionine (Ado...
Most organisms have developed ways to recognize and interact with other species. Symbiotic interactions range from pathogenic to mutualistic. Some molecular mechanisms of interspecific interaction are well und...
Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions of sequence-similar proteins has become available. O...
The impact on fitness of homozygous deletions in yeast has been shown to correlate with the rate of protein evolution assessed as the evolutionary distance between yeast and Caenorhabditis elegans.
Brevipalpus phoenicis, the false spider mite, has been shown to exist only in the haploid state.
Mouse μ-opioid receptor carboxy-terminal splice variants have been shown to differ in their responses to agonists.
Genomic and phylogenetic analyses have suggested that previously reported cases of putative lateral gene transfer from bacteria to vertebrates could result from gene losses and sampling artifacts.
A phylogenetic analysis has cast doubts on previously reported cases of putative horizontal gene transfer from bacteria to vertebrates.
Divergence of the sequences of reproductive genes has been accelerated by positive selection.
Time traces of GFP fluorescence expressed under the control of flagellar promoters have been used to order flagellar gene expression events in real time.
The first draft of human genome sequencing is complete. A large amount of DNA sequences are already available in the database but these are not ordered and assembled. In many cases, these sequences are shorter...
We have developed a series of programs, collectively packaged as Array File Maker 4.0 (AFM), that manipulate and manage DNA microarray data. AFM 4.0 is simple to use, applicable to any organism or microarray, ...
Comparison of the recently sequenced genome of the leprosy-causing pathogen Mycobacterium leprae with other mycobacterial genomes reveals a drastic gene reduction and decay in M. leprae affecting many metabolic a...
A response to Homologuephobia, by Gregory A Petsko, Genome Biology 2001 2:comment1002.1-1002.2, to An apology for orthologs - or brave new memes by Eugene V Koonin, Genome Biology 2001, 2:comment1005.1-1005.2, an...
A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based exp...
The large transforming growth factor-β (TGFβ) superfamily of secreted proteins regulate the growth, development and differentiation of cells in diverse organisms, including nematode worms, flies, mice and huma...
The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility all...
A computational system for analysis of the repetitive structure of genomic sequences is described. The method uses suffix trees to organize and search the input sequences; this data structure has been used pre...
A report on the Royal Society Discussion Meeting "The plant cell: between genome and plant", London, 13-14 June 2001.
A report on the Cold Spring Harbor meeting on Genome Sequencing and Biology, Cold Spring Harbor, NY, USA, 9-13 May 2001.
A response to The complete genome sequence of Vibrio cholerae : a tale of two chromosomes and of two lifestyles, by Gary K Schoolnik and Fitnat H Yildiz, Genome Biology 2000 1:reviews1016.1-1016.3.
We propose two different formulations of the Rasch statistical models to the problem of relating gene expression profiles to the phenotypes. One formulation allows us to investigate whether a cluster of genes ...
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