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Lipocalin killer

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In the August 3 Science, Laxminarayana Devireddy and colleagues from the University of Massachusetts Medical School report the use of DNA microarrays to identify genes whose expresssion is induced during apoptosis (Science 2001, 293:829-834). They studied cell death of a mouse pro-B lymphocytic cell line upon withdrawl of interleukin-3. The gene that showed the largest induction (12.6-fold) was 24p3, which encodes a lipocalin. Lipocalins are small secreted proteins, and Devireddy et al. found that conditioned medium from dying lymphocytes induced cell death in a range of leukocytic cells. Recombinant 24p3 protein alone could also induce lymphocyte apoptosis. The cell death induced by 24p3 probably plays a role in immune-system homeostasis and in the regulation of the inflammatory response. The authors point out how important the expression profiling approach was in leading them to a unidentified killer.

References

  1. 1.

    Science , [http://www.sciencemag.org]

  2. 2.

    University of Massachusetts Medical School , [http://www.umassmed.edu]

  3. 3.

    The Lipocalin Website, [http://www.jenner.ac.uk/lipocalin.htm]

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Keywords

  • Cell Death
  • Medical School
  • Conditioned Medium
  • 24p3 Protein
  • Secrete Protein