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A few dozen genes are known on the human Y chromosome. The completion of the human genome sequence will allow identification of the remaining loci, which should shed further light on the function and evolution...
Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antis...
Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.
Identification of orthologous relationships between genes from widely divergent taxa allows partial reconstruction of the gene complement of ancestral genomes. C2H2 zinc-finger genes are one of the largest and...
Homeotic genes are key developmental regulators that are highly conserved throughout evolution. Their encoded homeoproteins function as transcription factors to control a wide range of developmental processes....
DNA sequences bound by transcription factors can be identified by fitting simple models to expression array data.
Infection with the bacterium Wolbachia is sufficient to establish a reproductive barrier between two otherwise compatible species of wasp, making Wolbachia a potential driving force in evolution.
Conserved domains (CD) in proteins play a crucial role in protein interactions, DNA binding, enzyme activity, and other important cellular processes. We proposed to study ratios of genes containing these domai...
Short RNAs of 21 or 22 nucleotides have been shown to mediate RNA interference.
The completion of the Arabidopsis thaliana (mustard weed) genome sequence constitutes a major breakthrough in plant biology. It will revolutionize how we answer questions about the biology and evolution of plants...
A unique arrangement of domains makes up the common region of two otherwise very different proteins - long, elegant dystrophin, and its rather dumpy distant cousin, dystrobrevin. The two work in concert, formi...
The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications an...
A report on the 'Integration of Signaling Pathways in Development' Keystone Symposium, Keystone, Colorado, USA, 27 January to 1 February 2001.
A report from Microbial Genomes, a joint conference of the American Society for Microbiology and the Institute for Genomic Research, Monterey, California, USA, 28-31 January, 2001.
A report on the 22nd Annual Lorne Conference on the Organization and Expression of the Genome, Lorne, Victoria, Australia, 11-15 February, 2001
Understanding the regulation of gene expression requires an analysis of gene-specific transcription factors. This review highlights recent work that uses protein-DNA crosslinking, immunoprecipitation and DNA m...
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