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  1. MOLMOL is a molecular graphics program designed for display and analysis of biological macromolecules, particularly protein or DNA structures determined by nuclear magnetic resonance spectroscopy.

    Authors: Jarrod A Smith
    Citation: Genome Biology 2000 1:reports2046
  2. Since its inception in 1996, Pfam has aimed to be a comprehensive database of protein families defined by the presence of shared domains.

    Authors: Colin Semple
    Citation: Genome Biology 2000 1:reports2044
  3. Specific DNA targets of chromatin-associated factors have been enzymatically marked in order to identify loci that are regulated at the level of chromatin organization in eukaryotes.

    Authors: Michaela Torkar
    Citation: Genome Biology 2000 1:reports0051
  4. Small RNAs involved in rRNA methylation and ribosome biogenesis have been found in Archaea.

    Authors: Rachel Brem
    Citation: Genome Biology 2000 1:reports0050
  5. Large quantities of biologically active human somatotropin have been successfully produced in plants, highlighting the promise of plant biotechnology for producing pharmaceuticals.

    Authors: Todd Richmond
    Citation: Genome Biology 2000 1:reports0049
  6. Systematic analysis of the chloroplast and its photosynthetic machinery has begun, using a combination of two-dimensional gels, mass spectroscopy, protein sequencing and genome databases.

    Authors: Todd Richmond
    Citation: Genome Biology 2000 1:reports0048
  7. A portion of the rice genome has been examined in order to evaluate the feasibility of using rice as a surrogate genome for map-based cloning of maize genes.

    Authors: Todd Richmond
    Citation: Genome Biology 2000 1:reports0047
  8. A meeting report of the sessions on human, eukaryotic and bacterial genome sequencing at the American Society for Microbiology and Institut Pasteur joint conference: Genomes 2000 International Conference on Mi...

    Authors: Andrew JG Simpson
    Citation: Genome Biology 2000 1:reports411.1
  9. A report of work on the structure and function of the nuclear envelope and nuclear pores, presented at the 39th annual meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999.

    Authors: Jason Swedlow
    Citation: Genome Biology 2000 1:reports407.1
  10. Living cells organize their internal contents by coordinating the chaotic thermal motion of protein molecules. A recent study, combining experiment with stochastic simulation, shows how this might be achieved ...

    Authors: Dennis Bray
    Citation: Genome Biology 2000 1:reviews108.1
  11. Recent sequence and cytogenetic analyses of heterochromatin in Arabidopsis, together with other results from Arabidopsis and maize, indicate that plant heterochromatin can have very different origins, composition...

    Authors: Jeffrey L Bennetzen
    Citation: Genome Biology 2000 1:reviews107.1
  12. Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems.

    Authors: Ruslan Medzhitov and Charles Janeway Jr.
    Citation: Genome Biology 2000 1:reviews106.1
  13. Proteins of the Rab and SNARE families target vesicles to their intracellular destinations. A comparison of these families from the budding yeast, fission yeast, nematode and fruitfly genomes has implications ...

    Authors: John Armstrong
    Citation: Genome Biology 2000 1:reviews104.1
  14. Genomic sequencing of the Toll-like receptor 4 gene in humans, mice, chimpanzee and baboon has shown that the Tlr4 protein is polymorphic.

    Authors: Ann-Marie Mallon
    Citation: Genome Biology 2000 1:reports040
  15. Clever use of a mutation that allows tetrad analysis in a higher plant has enabled researchers to map the centromeres of Arabidopsis genetically with high precision.

    Authors: Todd Richmond
    Citation: Genome Biology 2000 1:reports039
  16. The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individua...

    Authors: Andrew W Murray
    Citation: Genome Biology 2000 1:comment003.1
  17. On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional grou...

    Authors: Nicholas M Luscombe, Susan E Austin, Helen M Berman and Janet M Thornton
    Citation: Genome Biology 2000 1:reviews001.1

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