Open Access

Bloom-in' flies

  • Jonathan B Weitzman
Genome Biology20012:spotlight-20010403-04

https://doi.org/10.1186/gb-spotlight-20010403-04

Published: 03 April 2001

Bloom syndrome is a disease characterized by increased tumorigenesis, immunodeficiency and partial sterility. It is caused by mutations in the BLMgene, which encodes a helicase. In the March 30th Science, Kusano et al. describe characterization of the Drosophila Dmblm homolog of BLM (Science 2001, 291:2600-2602). They show that Dmblm corresponds to mus309, which was originally identified in a mutagen-sensitivity screen. Disrupting the Dmblm gene causes mutagen sensitivity and female sterility, whereas transgenic flies expressing Dmblm rescue the mus309 phenotypes. Kusano et al. also show that transgenic flies expressing the DNA-repair gene Ku70 could rescue mus309 phenotypes, implicating Dmblm in the pathways that repair double-strand DNA breaks. Consistently, mus309 male sperm show evidence for increased nondisjunction and chromosome loss.

References

  1. Molecular genetics of Bloom's syndrome.Google Scholar
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  3. Science, [http://www.sciencemag.org]
  4. Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene.Google Scholar
  5. Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster.Google Scholar

Copyright

© BioMed Central Ltd 2001

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