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Leprosy locus

There appears to be a genetic contribution to the susceptibility to leprosy, and high concordance rates have been observed amongst monozygotic Indian twins. In the April Nature Genetics, Siddiqui et al. report the identification of a major susceptibility locus for leprosy (Nature Genetics 2001, 27:439-441). They performed a genome-wide scan of 245 independent affected sibpairs from Southern India, using 396 highly polymorphic microsatellite markers. Only one region showed a MLS (maximum lod score) or more than 3.0: the marker D10S1661 on chromosome 10p13 has a MLS of 4.09, above the threshold for statistical significance. These results attest to the feasibility of genome-wide linkage studies in the genetic analysis of complex prevalent infectious diseases.


  1. Genetic epidemiology of the susceptibility to leprosy.

  2. Nature Genetics, []

  3. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.

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Weitzman, J.B. Leprosy locus. Genome Biol 2, spotlight-20010406-01 (2001).

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