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  1. A report from the minisymposium on regulated secretion at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999

    Authors: Colin Jamora
    Citation: Genome Biology 2000 1:reports402.1
  2. Launched in September 1998, dbSNP is the central repository for data on single-nucleotide polymorphisms (SNPs), the most common form of sequence variation in human populations.

    Authors: Colin Semple
    Citation: Genome Biology 2000 1:reports243
  3. The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define...

    Authors: Charles Brenner
    Citation: Genome Biology 2000 1:reviews103.1
  4. For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [

    Authors: Anne Ridley
    Citation: Genome Biology 2000 1:reviews102.1
  5. The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusion...

    Authors: Claire E Walczak
    Citation: Genome Biology 2000 1:reviews101.1
  6. Serial analysis of gene expression (SAGE) has been used to analyze the complete human 'transcriptome' - the number, identity and level of expression of genes in humans.

    Authors: Hamish Scott
    Citation: Genome Biology 2000 1:reports031
  7. Members of the Arabidopsis Genome Initiative, primarily from The Institute for Genomic Research, have completed sequencing one of the first two plant chromosomes.

    Authors: Todd Richmond
    Citation: Genome Biology 2000 1:reports029
  8. PCR screening five collections of mutagenized Arabidopsis lines to find those that have T-DNA or transposon insertions in 73 members of the R2R3 MYB gene family has identified 47 insertions into 36 genes.

    Authors: Seung Yon Rhee
    Citation: Genome Biology 2000 1:reports025
  9. Systems analysis of the complete genome sequence combined with biochemical information on metabolic pathways has been used to define and elucidate the relationship between genotype and phenotype for Haemophilus i...

    Authors: Mary Wildermuth
    Citation: Genome Biology 2000 1:reports016
  10. Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that resistance to LPS is caused by defects in the Toll-lik...

    Authors: Irina Smirnova, Alexander Poltorak, Edward KL Chan, Colleen McBride and Bruce Beutler
    Citation: Genome Biology 2000 1:research002.1
  11. The formin family of proteins has been implicated in signaling pathways of cellular morphogenesis in both animals and fungi; in the latter case, at least, they participate in communication between the actin cy...

    Authors: Fatima Cvrcková
    Citation: Genome Biology 2000 1:research001.1
  12. The use of cDNA microarrays for the study and mapping of gene amplifications and deletions on a whole-genome scale provides a comparison of DNA copy numbers in normal and tumor cells at unprecedented resolution.

    Authors: Aude Fahrer
    Citation: Genome Biology 2000 1:reports011
  13. The particular interest of David Ussery and his group is in creating 'structural atlases' of genomes from a detailed analysis of variations in DNA structure.

    Authors: Shuba Gopal
    Citation: Genome Biology 2000 1:reports231
  14. For those interested in DT40, a chick pre-B-cell line proving increasingly popular for use in gene targeting projects, this is a very useful site.

    Authors: Julie Curran
    Citation: Genome Biology 2000 1:reports227
  15. Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.

    Authors: Mar Albà
    Citation: Genome Biology 2000 1:reports225
  16. The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegansand humans.

    Authors: Todd Richmond
    Citation: Genome Biology 2000 1:reports223
  17. Data are collected from Nature, Science, Cell, and Nature Cell Biologyto form a database and resource for the signaling pathways of human cells.

    Authors: Iain Gilfillan
    Citation: Genome Biology 2000 1:reports221
  18. This online version of a US Department of Energy publication provides detailed background information about the human genome project.

    Authors: Basil Safwat
    Citation: Genome Biology 2000 1:reports215
  19. This site has a collection of features dealing with different areas of genetic research, and is an interesting and useful piece of 'popular science'.

    Authors: Basil Safwat
    Citation: Genome Biology 2000 1:reports213
  20. The puffer fish Fugu rubripes is perhaps better known as a Japanese delicacy, but its gene-rich, relatively small genome makes the puffer fish a suitable vertebrate for comparative mapping.

    Authors: Aengus Stewart
    Citation: Genome Biology 2000 1:reports210
  21. This comprehensive online biology reference book consists of lists of terms covering an extensive range of biological topics, and is aimed primarily at graduate students.

    Authors: Ines Chyla
    Citation: Genome Biology 2000 1:reports207
  22. A great site for anyone interested in breast cancer or mammary gland development - beginners and experienced researchers alike.

    Authors: Bryony Wiseman
    Citation: Genome Biology 2000 1:reports206
  23. SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC mole...

    Authors: Christopher J Thorpe
    Citation: Genome Biology 2000 1:reports203
  24. The first publication of the genomic sequence of an entire human chromosome.

    Authors: Jonathan B Weitzman
    Citation: Genome Biology 2000 1:reports019
  25. Plant defense responses are induced by recognition of a conserved epitope of the major protein of the bacterial flagellum. This could represent a general perception mechanism for plants to detect infection by ...

    Authors: William Deakin
    Citation: Genome Biology 2000 1:reports013
  26. Bioinformatic analysis has been used to identify gene-fusion events in complete genomes and thus infer protein interactions on the basis of sequence analysis alone.

    Authors: Paul Kellam
    Citation: Genome Biology 2000 1:reports009
  27. The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.

    Authors: William Deakin
    Citation: Genome Biology 2000 1:reports007
  28. Protein virulence factors can be secreted from bacterial cells using the machinery used to assemble the flagellum.

    Authors: William Deakin
    Citation: Genome Biology 2000 1:reports003
  29. Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.

    Authors: Jonathan B Weitzman
    Citation: Genome Biology 2000 1:reports002
  30. YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host de...

    Authors: Jonathan B Weitzman
    Citation: Genome Biology 2000 1:reports001

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