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DNA sequences bound by transcription factors can be identified by fitting simple models to expression array data.
Infection with the bacterium Wolbachia is sufficient to establish a reproductive barrier between two otherwise compatible species of wasp, making Wolbachia a potential driving force in evolution.
Conserved domains (CD) in proteins play a crucial role in protein interactions, DNA binding, enzyme activity, and other important cellular processes. We proposed to study ratios of genes containing these domai...
Short RNAs of 21 or 22 nucleotides have been shown to mediate RNA interference.
The completion of the Arabidopsis thaliana (mustard weed) genome sequence constitutes a major breakthrough in plant biology. It will revolutionize how we answer questions about the biology and evolution of plants...
A unique arrangement of domains makes up the common region of two otherwise very different proteins - long, elegant dystrophin, and its rather dumpy distant cousin, dystrobrevin. The two work in concert, formi...
The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications an...
A report on the 'Integration of Signaling Pathways in Development' Keystone Symposium, Keystone, Colorado, USA, 27 January to 1 February 2001.
A report from Microbial Genomes, a joint conference of the American Society for Microbiology and the Institute for Genomic Research, Monterey, California, USA, 28-31 January, 2001.
A report on the 22nd Annual Lorne Conference on the Organization and Expression of the Genome, Lorne, Victoria, Australia, 11-15 February, 2001
Understanding the regulation of gene expression requires an analysis of gene-specific transcription factors. This review highlights recent work that uses protein-DNA crosslinking, immunoprecipitation and DNA m...
Phylogenetic analyses of gene sequences provide a clear pattern of which extant flowering plant genera diversified earliest. Combined with complete genomic sequences, these data will vastly improve understandi...
Over the past five years, interest in and use of DNA array technology has increased dramatically, and there has been a surge in demand for different types of arrays. Although manufacturers offer a number of pr...
The arginine repressor ArgR/AhrC is a transcription factor universally conserved in bacterial genomes. Its recognition signal (the ARG box), a weak palindrome, is also conserved between genomes, despite a very...
We propose that a computerized, internet-based graphical description language for systems biology will be essential for describing, archiving and analyzing complex problems of biological function in health and...
Correlations between genome composition (in terms of GC content) and usage of particular codons and amino acids have been widely reported, but poorly explained. We show here that a simple model of processes ac...
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