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The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individua...
On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional grou...
The use of cDNA arrays has allowed monitoring of the change in expression of host cell genes during HIV-1 infection.
Error-free protein plus nucleic acid libraries have been generated by fusing mRNA to expressed protein and selecting for full-length proteins.
Genome-wide yeast two-hybrid screening has provided a census of protein-protein interactions in Saccharomyces cerevisiae.
DNA microarray analysis has been used for the first time to define clinically relevant subtypes of lymphoma.
Information about the set of amino-acid sequences that will fold to a given target protein structure can be predicted without assuming complete knowledge of the possible conformational space they can occupy.
The nucleotide sequence of the 120 megabase euchromatic region of the Drosophila melanogaster genome is reported.
Transcriptional analysis has been used to probe the biology of mycobacterial responses to antibiotics and to suggest new drug targets.
Expression patterns of Vibrio cholerae virulence genes determined during an infection differ dramatically from those observed in conventional in vitro analyses.
A new technique for the selection of newly synthesized DNA has enabled the selection and amplification of putative origins of replication on the human X chromosome.
A report from the "Quantitative challenges in the post-genomic sequence era" workshop and symposium, San Diego, January 11-15, 2000
A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
The NCBI human/mouse homology map compares the position of genes and other loci in homologous segments of DNA from human and mouse sources.
Given the variety of codon usage by different organisms and organelles, this centralized codon-usage resource is invaluable.
The unified database (UDB) attempts to create an integrated map based on human genome mapping data retrieved from a number of public databases.
The sequence tag alignment and consensus knowledgebase (STACK) is an international collaborative project on EST clustering.
Finding the relevant database is not always easy, and for some years Nucleic Acids Research has dedicated its first issue of the year to information about the most important existing databases.
A sensitive coexpression algorithm detects new genes associated with markers of prostate cancer.
Mouse chromosomes carrying deletions have been produced using a combination of targeted and random integration of selectable markers followed by specific excision by a recombinase.
A statistical analysis of simple repeat motifs in DNA across the Escherichia coli genome is described.
Many protein-protein interactions are identified at once using high-throughput yeast two-hybrid screens.
The entire human major histocompatibility complex (MHC), a genomic region critical for immune defense, has been sequenced.
Correlation-based clustering of plant expressed sequence tags allows conclusions to be drawn about the relationship between genes based on their expression patterns in different tissues.
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