- Web report
- Open Access
A high-quality database of molecules of the immune system
- Christopher J Thorpe
© BioMed Central Ltd 2000
- Received: 1 September 1999
- Published: 17 March 2000
This integrated immunogenetics database specializes in immunoglobulins, T-cell receptors and major histocompatibility complex (MHC) molecules.
- Major Histocompatibility Complex
- Major Histocompatibility Complex Molecule
- Search Function
- European Bioinformatics Institute
- Receptor Lineage
This integrated immunogenetics database specializes in immunoglobulins, T-cell receptors and major histocompatibility complex (MHC) molecules. First created in 1989, the database has been a European project since 1992, and is maintained in close collaboration with the European Bioinformatics Institute (EBI). IMGT is composed of two major databases: IMTT/LIGM-DB, a database of immunoglobulin and T-cell receptors from humans and other vertebrates; and IMGT/HLA-DB, a database of human MHC molecules (HLA). The site also contains annotated illustrations of secondary structure and crystallographic structures.
The site is regularly updated and each page is stamped with a creation date and a modification date. Most pages appeared to have been updated within the previous month.
The most important feature of this site is the clear categorization and display of sequences. The alignments of genes in specific immunoglobulin and T-cell receptor lineages clearly show the important features - the sequence changes - by only showing differences from a prototypic sequence. This, coupled with the regular updates, makes the site an important resource.
The search function is in need of alteration. Search results, which are generated by an external search engine, are difficult to rank for importance, and do not always lead directly to the desired sequence; but given that navigation in the site is good, this is not a serious problem.
Additional human MHC information is available from HLA Informatics Group, Anthony Nolan Bone Marrow Trust.