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As key regulators of gene expression in eukaryotes, small RNAs have been characterized in many seed plants, and pathways for their biogenesis, degradation, and action have been defined in model angiosperms. Ho...
Accurate assessment of health disparities requires unbiased knowledge of genetic risks in different populations. Unfortunately, most genome-wide association studies use genotyping arrays and European samples. ...
The Research Highlight to this article has been published in Genome Medicine 2018 10:100
The papaya Y-linked region showed clear population structure, resulting in the detection of the ancestral male population that domesticated hermaphrodite papayas were selected from. The same populations were u...
Although hybridization is thought to be relatively rare in animals, the raw genetic material introduced via introgression may play an important role in fueling adaptation and adaptive radiation. The butterfly ...
Two recent studies have added microarrays to the toolkit used to analyze the origins of replication in yeast chromosomes, providing a fuller picture of how genomic DNA replication is organized.
Sex determination in the flowers of maize involves the abortion of stamen or pistil development. Recent work investigating genes that control this process reveals that a microRNA is involved in both the sex de...
A report on the Keystone Symposium 'Comparative Genomics of Plants', Taos, USA, 4-9 March 2004.
The recently published genomic sequence of Xylella fastidiosa is the first for a free-living plant pathogen and provides clues to mechanisms of pathogenesis and survival in insect vectors. The sequence data shoul...
Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homol...
A revised root for the Y chromosome phylogeny further fragments the picture of modern human origins that can be reconstructed from genetic, linguistic and archaeological data.
A report on the main symposium 'Exploiting genomes: from bases to megabases in 50 years' at the 153rd Meeting of the Society for General Microbiology (SGM), Manchester, UK, 8-9 September 2003.
Ever since its invention, the polymerase chain reaction has been the method of choice for work with ancient DNA. In an application of modern genomic methods to material from the Pleistocene, a recent study has...
An intriguing recent study examines the role of miR-1202, a glutamate receptor regulating microRNA, in regulating major depressive disorder.
Vibrio cholerae O1 has figured prominently in the history of infectious diseases as a cause of periodic global epidemics, an affliction of refugees in areas of social strife and as the disease first subjected to ...
Those studying the genus Brassica will be among the early beneficiaries of the now-completed Arabidopsis sequence. The remarkable morphological diversity of Brassica species and their relatives offers valuable op...
A report on the 46th Annual Maize Genetics Conference, Mexico City, Mexico, 11-14 March 2004.
The sequence of chimpanzee chromosome 22 is starting to help us to define the set of genetic attributes that are unique to humans, but interpreting the biological consequences of these remains a major challenge.
A report on the 64th annual American Society of Human Genetics meeting held in San Diego, USA, 18-22 October, 2014.
A recent study using cell-based assays together with an olfactory psychophysical survey in humans has established a link between a genetic polymorphism in an odorant receptor and variability in perception of t...
Horizontal gene transfer (HGT) has a far more significant role than gene duplication in bacterial evolution. This has recently been illustrated by work demonstrating the importance of HGT in the emergence of b...
A report on the 13th International Congress on Yeasts (ICY), held at Madison, Wisconsin, USA, 26-30 August 2012.
A report on the 16th International Arabidopsis Conference, Madison, USA, 15-19 June 2005.
Genome-scale models require an objective function representing what an organism strives for. A method has been developed to infer this fundamental biological function from data.
The biological arms race generally involves the rapid co-evolution of anti-virus systems in host organisms and of anti-anti-virus systems in their viral parasites. The CRISPR-Cas system is an example of a prok...
A recent study used 61 extant animal genomes to reconstruct the chromosomes of the hypothetical amniote ancestor. Comparison of this karyotype to the 17 chordate linkage groups previously inferred in the ances...
A selection of evaluations from Faculty of 1000 covering the quantification of proteins and phosphoproteins, haplotype structure in Arabidopsis, genomewide analysis of small interfering RNAs, screening newborns f...
This article is part of a Supplement: Volume 11 Supplement 1
This article is part of a Supplement: Volume 11 Supplement 1
A selection of evaluations from Faculty of 1000 covering a TATA-box binding protein survey; Arabidopsis enzyme-activity profiling; cis-regulatory systems in Ascomycetes; Candida comparative genomics; a functional...
All members of the species Plasmodium falciparum seem to have been derived from a single recent ancestor.
SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC mole...
A selection of evaluations from Faculty of 1000 covering p53 gene silencing, Arabidopsis genome duplications, RNA interference and disease protection, environmental gene diversity and predicting RNA folding patte...
The NCBI human/mouse homology map compares the position of genes and other loci in homologous segments of DNA from human and mouse sources.
The original article was published in Genome Biology 2009 9:245
This article is part of a Supplement: Volume 12 Supplement 1
A selection of evaluations from Faculty of 1000 covering the proteomics of macromolecular complexes, verification of microarray data, a transcript map of chromosome 22, arraying maize tissue-specific genes and pr...
MicroRNAs are non-coding small RNAs of ~22 nucleotides that regulate the gene expression by base-paring with target mRNAs, leading to mRNA cleavage or translational repression. It is currently estimated that m...
The original article was published in Genome Biology 2024 25:151
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