- Poster presentation
- Open Access
Evolution of the protein domain repertoire of eukaryotes reveals strong functional patterns
© Zmasek and Godzik; licensee BioMed Central Ltd. 2010
- Published: 11 October 2010
- Gene Ontology
- Eukaryotic Genome
- Pfam Domain
- Functional Profile
- Domain Loss
Eukaryotes exhibit massive variation in their morphological complexity, ranging from protists to basal animals, such as Trichoplax adhaerens with only four different cell types, to mammals with ~ 210 different cell types . Yet, the number of protein coding genes in eukaryotic genomes remains remarkably constant. Here, we attempt to shed some light on this paradox by analyzing eukaryotic genome evolution with a protein function centric view.
Complete sets of predicted proteins for 114 eukaryotic genomes were analyzed with HMMER3 for Pfam domains. Ancestral domain sets were reconstructed using Dollo parsimony. Over- represented gene ontology (GO) terms were determined with Ontologizer 2.0.
This article is published under license to BioMed Central Ltd.