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Volume 8 Supplement 1

Transposons in vertebrate functional genomics


Edited by Stephen C Ekker and Zoltán Ivics

  1. To meet the increasing demand of linking sequence information to gene function in vertebrate models, genetic modifications must be introduced and their effects analyzed in an easy, controlled, and scalable man...

    Authors: Lajos Mátés, Zsuzsanna Izsvák and Zoltán Ivics
    Citation: Genome Biology 2007 8(Suppl 1):S1
  2. Transposons are powerful tools for conducting genetic manipulation and functional studies in organisms that are of scientific, economic, or medical interest. Minos, a member of the Tc1/mariner family of DNA trans...

    Authors: Anastasios Pavlopoulos, Stefan Oehler, Maria G Kapetanaki and Charalambos Savakis
    Citation: Genome Biology 2007 8(Suppl 1):S2
  3. Achievement of transposon mediated germline transgenesis in a basal chordate, Ciona intestinalis, is discussed. A Tc1/mariner superfamily transposon, Minos, has excision and transposition activities in Ciona. Min...

    Authors: Yasunori Sasakura, Yuichi Oogai, Terumi Matsuoka, Nori Satoh and Satoko Awazu
    Citation: Genome Biology 2007 8(Suppl 1):S3
  4. A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovere...

    Authors: Hiroshi Kikuta, David Fredman, Silke Rinkwitz, Boris Lenhard and Thomas S Becker
    Citation: Genome Biology 2007 8(Suppl 1):S4
  5. Although alterations in the genomes of somatic cells cannot be passed on to future generations, they can have beneficial or detrimental effects on the host organism, depending on the context in which they occu...

    Authors: Lara S Collier and David A Largaespada
    Citation: Genome Biology 2007 8(Suppl 1):S5
  6. The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional transposase. The transposase protein can catalyze transposition of a transposon construct that has 200 and 150 base pairs o...

    Authors: Koichi Kawakami
    Citation: Genome Biology 2007 8(Suppl 1):S7
  7. We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mecha...

    Authors: Sridhar Sivasubbu, Darius Balciunas, Adam Amsterdam and Stephen C Ekker
    Citation: Genome Biology 2007 8(Suppl 1):S9
  8. From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for....

    Authors: Clemens Grabher and Joachim Wittbrodt
    Citation: Genome Biology 2007 8(Suppl 1):S10
  9. The study of amphibian embryogenesis has provided important insight into the mechanisms of vertebrate development. The frog Xenopus laevis has been an important model of vertebrate cell biology and development fo...

    Authors: Donald A Yergeau and Paul E Mead
    Citation: Genome Biology 2007 8(Suppl 1):S11
  10. Viral and transposon vectors have been employed in gene therapy as well as functional genomics studies. However, the goals of gene therapy and functional genomics are entirely different; gene therapists hope t...

    Authors: Christopher S Hackett, Aron M Geurts and Perry B Hackett
    Citation: Genome Biology 2007 8(Suppl 1):S12
  11. Swine production has been an important part of our lives since the late Mesolithic or early Neolithic periods, and ranks number one in world meat production. Pig production also contributes to high-value-added...

    Authors: Karl J Clark, Daniel F Carlson and Scott C Fahrenkrug
    Citation: Genome Biology 2007 8(Suppl 1):S13
  12. The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic stud...

    Authors: Lara S Collier and David A Largaespada
    Citation: Genome Biology 2007 8(Suppl 1):S15
  13. LINE1 (L1) retrotransposons are genetic elements that are present in all mammalian genomes. L1s are active in both humans and mice, and are capable of copying themselves and inserting the copy into a new genom...

    Authors: Eric M Ostertag, Blair B Madison and Hiroki Kano
    Citation: Genome Biology 2007 8(Suppl 1):S16

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 10.1
    5-year Journal Impact Factor: 16.5
    Source Normalized Impact per Paper (SNIP): 2.521
    SCImago Journal Rank (SJR): 7.197

    Speed 2023
    Submission to first editorial decision (median days): 22
    Submission to acceptance (median days): 277

    Usage 2023
    Downloads: 6,688,476
    Altmetric mentions: 12,515

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