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Volume 8 Supplement 1

Transposons in vertebrate functional genomics


Edited by Stephen C Ekker and Zoltán Ivics

  1. Content type: Review

    To meet the increasing demand of linking sequence information to gene function in vertebrate models, genetic modifications must be introduced and their effects analyzed in an easy, controlled, and scalable man...

    Authors: Lajos Mátés, Zsuzsanna Izsvák and Zoltán Ivics

    Citation: Genome Biology 2007 8(Suppl 1):S1

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  2. Content type: Review

    Transposons are powerful tools for conducting genetic manipulation and functional studies in organisms that are of scientific, economic, or medical interest. Minos, a member of the Tc1/mariner family of DNA trans...

    Authors: Anastasios Pavlopoulos, Stefan Oehler, Maria G Kapetanaki and Charalambos Savakis

    Citation: Genome Biology 2007 8(Suppl 1):S2

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  3. Content type: Review

    Achievement of transposon mediated germline transgenesis in a basal chordate, Ciona intestinalis, is discussed. A Tc1/mariner superfamily transposon, Minos, has excision and transposition activities in Ciona. Min...

    Authors: Yasunori Sasakura, Yuichi Oogai, Terumi Matsuoka, Nori Satoh and Satoko Awazu

    Citation: Genome Biology 2007 8(Suppl 1):S3

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  4. Content type: Review

    A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovere...

    Authors: Hiroshi Kikuta, David Fredman, Silke Rinkwitz, Boris Lenhard and Thomas S Becker

    Citation: Genome Biology 2007 8(Suppl 1):S4

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  5. Content type: Review

    Although alterations in the genomes of somatic cells cannot be passed on to future generations, they can have beneficial or detrimental effects on the host organism, depending on the context in which they occu...

    Authors: Lara S Collier and David A Largaespada

    Citation: Genome Biology 2007 8(Suppl 1):S5

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  6. Content type: Review

    The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional transposase. The transposase protein can catalyze transposition of a transposon construct that has 200 and 150 base pairs o...

    Authors: Koichi Kawakami

    Citation: Genome Biology 2007 8(Suppl 1):S7

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  7. Content type: Review

    We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mecha...

    Authors: Sridhar Sivasubbu, Darius Balciunas, Adam Amsterdam and Stephen C Ekker

    Citation: Genome Biology 2007 8(Suppl 1):S9

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  8. Content type: Review

    From among a plethora of various gene delivery methods, the researcher must choose the right one according to availability for a given species and the precise application the transgenic animal is intended for....

    Authors: Clemens Grabher and Joachim Wittbrodt

    Citation: Genome Biology 2007 8(Suppl 1):S10

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  9. Content type: Review

    The study of amphibian embryogenesis has provided important insight into the mechanisms of vertebrate development. The frog Xenopus laevis has been an important model of vertebrate cell biology and development fo...

    Authors: Donald A Yergeau and Paul E Mead

    Citation: Genome Biology 2007 8(Suppl 1):S11

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  10. Content type: Review

    Viral and transposon vectors have been employed in gene therapy as well as functional genomics studies. However, the goals of gene therapy and functional genomics are entirely different; gene therapists hope t...

    Authors: Christopher S Hackett, Aron M Geurts and Perry B Hackett

    Citation: Genome Biology 2007 8(Suppl 1):S12

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  11. Content type: Review

    Swine production has been an important part of our lives since the late Mesolithic or early Neolithic periods, and ranks number one in world meat production. Pig production also contributes to high-value-added...

    Authors: Karl J Clark, Daniel F Carlson and Scott C Fahrenkrug

    Citation: Genome Biology 2007 8(Suppl 1):S13

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  12. Content type: Review

    The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic stud...

    Authors: Lara S Collier and David A Largaespada

    Citation: Genome Biology 2007 8(Suppl 1):S15

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  13. Content type: Review

    LINE1 (L1) retrotransposons are genetic elements that are present in all mammalian genomes. L1s are active in both humans and mice, and are capable of copying themselves and inserting the copy into a new genom...

    Authors: Eric M Ostertag, Blair B Madison and Hiroki Kano

    Citation: Genome Biology 2007 8(Suppl 1):S16

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