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Error-free protein plus nucleic acid libraries have been generated by fusing mRNA to expressed protein and selecting for full-length proteins.
DNA microarray analysis has been used for the first time to define clinically relevant subtypes of lymphoma.
Information about the set of amino-acid sequences that will fold to a given target protein structure can be predicted without assuming complete knowledge of the possible conformational space they can occupy.
The nucleotide sequence of the 120 megabase euchromatic region of the Drosophila melanogaster genome is reported.
Transcriptional analysis has been used to probe the biology of mycobacterial responses to antibiotics and to suggest new drug targets.
Expression patterns of Vibrio cholerae virulence genes determined during an infection differ dramatically from those observed in conventional in vitro analyses.
A new technique for the selection of newly synthesized DNA has enabled the selection and amplification of putative origins of replication on the human X chromosome.
A report from the "Quantitative challenges in the post-genomic sequence era" workshop and symposium, San Diego, January 11-15, 2000
A report on work presented at the 39th Annual Meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999
A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
A report on work with small-molecule inhibitors of cellular processes presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
A report from the minisymposium on regulated secretion at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
Launched in September 1998, dbSNP is the central repository for data on single-nucleotide polymorphisms (SNPs), the most common form of sequence variation in human populations.
The NCBI human/mouse homology map compares the position of genes and other loci in homologous segments of DNA from human and mouse sources.
Given the variety of codon usage by different organisms and organelles, this centralized codon-usage resource is invaluable.
The purpose of CODEHOP is to help in the design of degenerate PCR primers from protein sequence.
For those interested in genome-wide or more restricted comparisons of proteins across species, the Clusters of Orthologous Groups (COGs) website provides the kind of information many of us want.
The unified database (UDB) attempts to create an integrated map based on human genome mapping data retrieved from a number of public databases.
The sequence tag alignment and consensus knowledgebase (STACK) is an international collaborative project on EST clustering.
The Protomap program classifies proteins into clusters according to sequence similarity.
Finding the relevant database is not always easy, and for some years Nucleic Acids Research has dedicated its first issue of the year to information about the most important existing databases.
For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [
GeneCalling, a new expression profiling technique, has been used to elucidate regulatory gene networks in plants.
A sensitive coexpression algorithm detects new genes associated with markers of prostate cancer.
A novel method for the synthesis of 5'-attached oligonucleotides that eliminates truncated sequences may improve microarray construction.
Serial analysis of gene expression (SAGE) has been used to analyze the complete human 'transcriptome' - the number, identity and level of expression of genes in humans.
Members of the Arabidopsis Genome Initiative, including the European Union Arabidopsis Genome Sequencing Consortium and The Cold Spring Harbor, Washington University in St Louis and PE Biosystems Arabidopsis Sequ...
Members of the Arabidopsis Genome Initiative, primarily from The Institute for Genomic Research, have completed sequencing one of the first two plant chromosomes.
A maize transposable element has been used to generate a tool for identifying gene function in Arabidopsis thaliana.
Mouse chromosomes carrying deletions have been produced using a combination of targeted and random integration of selectable markers followed by specific excision by a recombinase.
A statistical analysis of simple repeat motifs in DNA across the Escherichia coli genome is described.
PCR screening five collections of mutagenized Arabidopsis lines to find those that have T-DNA or transposon insertions in 73 members of the R2R3 MYB gene family has identified 47 insertions into 36 genes.
A new noninvasive technique has been developed that successfully measures calcium dynamics in single Arabidopsis guard cells.
Many protein-protein interactions are identified at once using high-throughput yeast two-hybrid screens.
The design and testing of a neural network to predict phosphorylation sites on proteins is described.
The entire human major histocompatibility complex (MHC), a genomic region critical for immune defense, has been sequenced.
The crystal structure of human SRP54M from the signal recognition particle (SRP) reveals a homodimer interaction, which may be a model for the way signal sequences on nascent proteins recognize and activate th...
Correlation-based clustering of plant expressed sequence tags allows conclusions to be drawn about the relationship between genes based on their expression patterns in different tissues.
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