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By catalyzing the joining of breaks in the phosphodiester backbone of duplex DNA, DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Three related classes of A...
Analysis of the entire genome sequence of Clostridium perfringens will help explain how gas gangrene develops in humans
A biocomputational study of the fruitfly genome reveals the presence of new genes putatively involved in fucosylation
The entire Brucella melitensis genome sequence could pave the way to a vaccine against brucellosis in humans
A Listeria monocytogenes glucose-6-phosphate translocase shows how parasitic bacteria can use molecular mimicry to survive within eukaryotic host cells
Methods for extracting useful information from the datasets produced by microarray experiments are at present of much interest. Here we present new methods for finding gene sets that are well suited for distin...
In computational analysis, the RING-finger domain is one of the most frequently detected domains in the Arabidopsis proteome. In fact, it is more abundant in Arabidopsis than in other eukaryotic genomes. However,...
Homeobox genes of the orthodenticle (otd)/Otx family have conserved roles in the embryogenesis of head and brain. Gene replacement experiments show that the Drosophila otd gene and orthologous mammalian Otx genes...
Studies of DNA repair and the maintenance of genomic integrity are essential to understanding the etiology and pathology of cancer. The availability of the complete genome sequence of Saccharomyces cerevissiae ha...
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative prot...
The E-CELL simulation environment site is dedicated to the software tool E-CELL, which simulates biochemical interactions in cells in order to understand regulation at the level of a whole cell or organelle
Large-scale microarray analyses have provided insights into the genetic control of antibiotic production by Streptomyces coelicolor
Gene-expression studies have identified two new parasite genes potentially involved in the progression of Leishmania infection in mammalian hosts
The expression of several heat-shock proteins of nitrogen-fixing bacteria is controlled post-transcriptionally by the thermosensitive secondary structure of the 'ROSE' regulatory sequences in their mRNA
Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, u...
A recent study has used serial analysis of gene expression to compare mouse forelimb and hindlimb gene-expression profiles. The method successfully identified known regulators of limb identity and has generate...
Protein kinase C (PKC) has become a major focus among cell biologists interested in second-messenger signal transduction and much has been learned about differences in the cellular localization and function of...
The soluble glutathione transferases (GSTs, EC 2.5.1.18) are encoded by a large and diverse gene family in plants, which can be divided on the basis of sequence identity into the phi, tau, theta, zeta and lamb...
When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA...
A report on the Jackson Laboratory 'Genomics meets nanoscience' meeting, Bar Harbor, USA, 9-12 October 2001.
An erratum to The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis by AJ Furley. Genome Biology 2001, 2:reviews1026.1-1026.5
The original article was published in Genome Biology 2001 2:reviews1026.1
The fission yeast Schizosaccharomyces pombe has long been a model organism for studies of eukaryotic cells, winning renown especially for studies of the cell cycle. Now that its genome has been sequenced, S. pomb...
Genome sequence comparisons reveal that some sets of genes are in similar linkage groups in different organisms while other sets are dispersed. Are some linkage groups maintained by chance, or is there an adva...
A large-scale study of regulated gene expression has identified novel genes that may be involved in zebrafish embryonic development
A generic method for purifying protein complexes coupled with mass spectroscopic identification has enabled part of the network of interactions within the yeast proteome to be unraveled
Sites in DNA that bind regulatory proteins can be detected computationally in various ways. Pattern discovery methods analyze collections of genes suspected to be co-regulated on the evidence, for example, of ...
Concepts of orthology and paralogy are become increasingly important as whole-genome comparison allows their identification in complete genomes. Functional specificity of proteins is assumed to be conserved am...
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