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8009 result(s) for 'evolutionary biology' within Genome Biology

1. Curing hemophilia A by NHEJ-mediated ectopic F8 insertion in the mouse

   Hemophilia A, a bleeding disorder resulting from F8 mutations, can only be cured by gene therapy. A promising strategy is CRISPR-Cas9-mediated precise insertion of F8 in hepatocytes at highly expressed gene loci,...

   Authors: Jian-Ping Zhang, Xin-Xin Cheng, Mei Zhao, Guo-Hua Li, Jing Xu, Feng Zhang, Meng-Di Yin, Fei-Ying Meng, Xin-Yue Dai, Ya-Wen Fu, Zhi-Xue Yang, Cameron Arakaki, Ruijun Jeanna Su, Wei Wen, Wen-Tian Wang, Wanqiu Chen…

   Citation: Genome Biology 2019 20:276

   Content type: Research Published on: 16 December 2019

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2. Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis

   Organophosphates are the most frequently and largely applied insecticide in the world due to their biodegradable nature. Gut microbes were shown to degrade organophosphates and cause intestinal dysfunction. Th...

   Authors: Ganesan Velmurugan, Tharmarajan Ramprasath, Krishnan Swaminathan, Gilles Mithieux, Jeyaprakash Rajendhran, Mani Dhivakar, Ayothi Parthasarathy, D.D. Venkatesh Babu, Leishman John Thumburaj, Allen J. Freddy, Vasudevan Dinakaran, Shanavas Syed Mohamed Puhari, Balakrishnan Rekha, Yacob Jenifer Christy, Sivakumar Anusha, Ganesan Divya…

   Citation: Genome Biology 2017 18:8

   Content type: Research Published on: 24 January 2017

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3. Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

   The IL23/Th17 pathway is essential for the onset of inflammatory bowel disease (IBD), yet the specific mechanism by which this pathway initiates the disease remains unknown. In this study, we identify the mech...

   Authors: Huiling Wang, Kang Chao, Siew Chien Ng, Alfa Hc Bai, Qiao Yu, Jun Yu, Manying Li, Yi Cui, Minhu Chen, Ji-Fan Hu and Shenghong Zhang

   Citation: Genome Biology 2016 17:58

   Content type: Research Published on: 30 March 2016

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4. The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1

   Males and females differ in cognitive functions and emotional processing, which in part have been associated with baseline sex differences in gene expression in the medial prefrontal cortex. Nevertheless, a gr...

   Authors: Florian Duclot and Mohamed Kabbaj

   Citation: Genome Biology 2015 16:256

   Content type: Research Published on: 2 December 2015

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5. Genetic properties of the MAGIC maize population: a new platform for high definition QTL mapping in Zea mays

   Maize (Zea mays) is a globally produced crop with broad genetic and phenotypic variation. New tools that improve our understanding of the genetic basis of quantitative traits are needed to guide predictive crop b...

   Authors: Matteo Dell’Acqua, Daniel M. Gatti, Giorgio Pea, Federica Cattonaro, Frederik Coppens, Gabriele Magris, Aye L. Hlaing, Htay H. Aung, Hilde Nelissen, Joke Baute, Elisabetta Frascaroli, Gary A. Churchill, Dirk Inzé, Michele Morgante and Mario Enrico Pè

   Citation: Genome Biology 2015 16:167

   Content type: Research Published on: 11 September 2015

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6. A comparative evaluation of hybrid error correction methods for error-prone long reads

   Third-generation sequencing technologies have advanced the progress of the biological research by generating reads that are substantially longer than second-generation sequencing technologies. However, their n...

   Authors: Shuhua Fu, Anqi Wang and Kin Fai Au

   Citation: Genome Biology 2019 20:26

   Content type: Research Published on: 4 February 2019

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7. Epigenetic supersimilarity of monozygotic twin pairs

   Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of monozygotic twins have been assumed to...

   Authors: Timothy E. Van Baak, Cristian Coarfa, Pierre-Antoine Dugué, Giovanni Fiorito, Eleonora Laritsky, Maria S. Baker, Noah J. Kessler, Jianrong Dong, Jack D. Duryea, Matt J. Silver, Ayden Saffari, Andrew M. Prentice, Sophie E. Moore, Akram Ghantous, Michael N. Routledge, Yun Yun Gong…

   Citation: Genome Biology 2018 19:2

   Content type: Research Published on: 9 January 2018

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8. Cell type-specific epigenetic links to schizophrenia risk in the brain

   The importance of cell type-specific epigenetic variation of non-coding regions in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are conspicuously lacking. We generate ce...

   Authors: Isabel Mendizabal, Stefano Berto, Noriyoshi Usui, Kazuya Toriumi, Paramita Chatterjee, Connor Douglas, Iksoo Huh, Hyeonsoo Jeong, Thomas Layman, Carol A. Tamminga, Todd M. Preuss, Genevieve Konopka and Soojin V. Yi

   Citation: Genome Biology 2019 20:135

   Content type: Research Published on: 9 July 2019

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9. Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

   Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer.

   Authors: Domenico Alessandro Silvestris, Ernesto Picardi, Valeriana Cesarini, Bruno Fosso, Nicolò Mangraviti, Luca Massimi, Maurizio Martini, Graziano Pesole, Franco Locatelli and Angela Gallo

   Citation: Genome Biology 2019 20:33

   Content type: Research Published on: 13 February 2019

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