Genetics Research Centre, Molecular and Clinical Sciences Institute, St George’s University of London, London, SW17 0RE, UK
Bram P. Prins & Yalda Jamshidi
Department of Public Health and Primary Care, MRC/BHF Cardiovascular Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Worts’ Causeway, Cambridge, CB1 8RN, UK
Bram P. Prins
Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA
Timothy J. Mead & Suneel S. Apte
Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA
Jennifer A. Brody
deCODE genetics/Amgen, Inc., 101, Reykjavik, Iceland
Gardar Sveinbjornsson, David O. Arnar, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm & Kari Stefansson
Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Ioanna Ntalla, Stefan Van Duijvenboden, Julia Ramirez, Helen R. Warren, Andrew Tinker & Patricia B. Munroe
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Ioanna Ntalla, Julia Ramirez, Helen R. Warren, Andrew Tinker & Patricia B. Munroe
Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
Nathan A. Bihlmeyer
Department of Medical Informatics Erasmus MC - University Medical Center, P.O. Box 2040, Rotterdam, 3000, CA, The Netherlands
Marten van den Berg
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark
Jette Bork-Jensen, Niels Grarup, Oluf Pedersen & Torben Hansen
Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, 34137, Trieste, Italy
Stefania Cappellani, Antonietta Robino & Sheila Ulivi
Institute of Cardiovascular Science, University College London, London, WC1E 6BT, UK
Stefan Van Duijvenboden & Pier D. Lambiase
Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15201, USA
Nikolai T. Klena, George C. Gabriel, Xiaoqin Liu, Cagri Gulec, Molly Schwartz & Cecilia W. Lo
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
Jeffrey Haessler & Charles Kooperberg
Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
Leanne M. Hall, Christopher P. Nelson & Nilesh J. Samani
Leicester NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
Leanne M. Hall, Christopher P. Nelson & Nilesh J. Samani
Cardiovascular Department, Ospedali Riuniti and University of Trieste, 34100, Trieste, Italy
Annamaria Iorio & Gianfranco Sinagra
CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), and Department of Biochemistry, Maastricht University, Universiteitssingel 60, Maastricht, 6229 ER, The Netherlands
Aaron Isaacs
Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam, The Netherlands
Aaron Isaacs & Cornelia M. van Duijn
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Ruifang Li-Gao & Dennis O. Mook-Kanamori
Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, 02118, USA
Honghuang Lin
Biostatistics Department, Boston University School of Public Health, Boston, MA, 02118, USA
Ching-Ti Liu
Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland
Leo-Pekka Lyytikäinen & Terho Lehtimäki
Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, 33014, Tampere, Finland
Leo-Pekka Lyytikäinen & Terho Lehtimäki
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Jonathan Marten & Caroline Hayward
Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, 39216, USA
Hao Mei
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Martina Müller-Nurasyid & Konstantin Strauch
Department of Medicine I, University Hospital Munich, Ludwig-Maximilians University, Munich, Germany
Martina Müller-Nurasyid, Moritz F. Sinner & Stefan Kääb
German Centre for Cardiovascular Research (DZHK); partner site: Munich Heart Alliance, Munich, Germany
Martina Müller-Nurasyid, Annette Peters, Moritz F. Sinner, Melanie Waldenberger & Stefan Kääb
Mechanical Engineering Department, University College London, London, WC1E 6BT, UK
Michele Orini
Barts Heart Centre, St Bartholomews Hospital, London, EC1A 7BE, UK
Michele Orini & Pier D. Lambiase
Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF GCRC, Glasgow, G12 8TA, UK
Sandosh Padmanabhan
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
Farid Radmanesh & Jonathan Rosand
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA
Farid Radmanesh, Niek Verweij, Christopher H. Newton-Cheh & Jonathan Rosand
Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands
Jessica van Setten & Folkert W. Asselbergs
Icelandic Heart Association, 201, Kopavogur, Iceland
Albert V. Smith & Vilmundur Gudnason
Department of Cardiology, Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland
Albert V. Smith & Vilmundur Gudnason
University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Niek Verweij, Rudolf A. de Boer, Peter van der Meer & Pim van der Harst
Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 2114.0, USA
Niek Verweij
Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, 17475, Greifswald, Germany
Stefan Weiss & Uwe Völker
DZHK (German Centre for Cardiovascular Research); Partner site Greifswald, 17475, Greifswald, Germany
Stefan Weiss, Stephan B. Felix, Uwe Völker, Henry Völzke & Marcus Dörr
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA
Alvaro Alonso
Department of Medicine, Landspitali University Hospital, 101, Reykjavik, Iceland
David O. Arnar
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
Michiel L. Bots & Ilonca Vaartjes
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Anna F. Dominiczak
Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, 3000 CA, The Netherlands
Mark Eijgelsheim
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, 02114, USA
Patrick T. Ellinor & Paul L. Huang
The Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Xiuqing Guo & Henry J. Lin
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Xiuqing Guo & Steven A. Lubitz
Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, 17475, Greifswald, Germany
Stephan B. Felix & Marcus Dörr
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, 20892, USA
Tamara B. Harris & Lenore J. Launer
Cardiovascular Health Research Unit and the Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA
Susan R. Heckbert
Department of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
J. W. Jukema & Stella Trompet
Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands
J. W. Jukema
Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
J. W. Jukema
Department of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland
Mika Kähönen
Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, 33014, Tampere, Finland
Mika Kähönen
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Jan A. Kors
Division of Nephrology & Hypertension, Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, 84109, USA
Man Li
Research Centre for Prevention and Health, Capital Region of Denmark, 2600, Glostrup, Denmark
Allan Linneberg
Department of Clinical Experimental Research, Rigshospitalet, 2600, Glostrup, Denmark
Allan Linneberg
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200.0, Copenhagen, Denmark
Allan Linneberg
Division of Cardiovascular Medicine, Stanford University, Stanford, CA, 94305, USA
Marco Perez
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Annette Peters & Melanie Waldenberger
German Center for Diabetes Research, Neuherberg, Germany
Annette Peters
Faculty of Medicine, University of Split, Split, Croatia
Ozren Polasek
Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, 98101, USA
Bruce M. Psaty
Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA
Bruce M. Psaty
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland
Olli T. Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20014, Turku, Finland
Olli T. Raitakari
Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA
Kenneth M. Rice
The Institute for Translational Genomics and Population Sciences and Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Jerome I. Rotter
Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Elsayed Z. Soliman
Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
Tim D. Spector
Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany
Konstantin Strauch
Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland
Unnur Thorsteinsdottir & Kari Stefansson
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Stella Trompet
Human Genotyping Facility Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, 3000 CA, The Netherlands
André Uitterlinden
Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany
Henry Völzke
Research unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Melanie Waldenberger
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA
James G. Wilson
TCM Clinical Basis Institute, Zhejiang Chinese Medical University, Hangzhou, 310000, Zhejiang, China
Zhijun Xie
Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, the Netherlands
Folkert W. Asselbergs & Pim van der Harst
Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK
Folkert W. Asselbergs
Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK
Folkert W. Asselbergs
Department of Medical, Surgical and Health Sciences, University of Trieste, 34100, Trieste, Italy
Paolo Gasparini
Division of Experimental Genetics, Sidra Medical and Research Center, Doha, Qatar
Paolo Gasparini
School of Engineering and Natural Sciences, University of Iceland, 101, Reykjavik, Iceland
Daniel F. Gudbjartsson
Laboratory of Experimental Cardiology, University of Copenhagen, 2200, Copenhagen, Denmark
Jørgen K. Kanters
Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA
Henry J. Lin
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Dennis O. Mook-Kanamori
Dubowitz Neuromuscular Centre, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
Francesco J. Conti
Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, MA, 02114, USA
Christopher H. Newton-Cheh
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Igor Rudan
Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
Blair H. Smith
Department of Epidemiology Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, 3000 CA, The Netherlands
Bruno H. Stricker
Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, 98101, USA
Nona Sotoodehnia
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Pim van der Harst
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
Dan E. Arking
Genetics Research Centre, Molecular and Clinical Sciences Institute, St George’s University of London, London, UK
Yalda Jamshidi
Supervision and management of the project: YJ. Study design: BPP, TJM, SSA, CWL, DEA, YJ. The manuscript was critically revised in detail by members of the writing team before circulation to all co-authors. Manuscript writing group: BPP, TJM, SSA, FJC, DEA, PvdH, CWL, YJ. All co-authors revised and approved the manuscript. Exome chip data analysis: BPP, JAB, NAB, MvdB, JB-J, SC, NG, JH, LMH, AI, AI, RL-G, HL, C-TL, L-PL, JM, HM, MM-N, SP, FR, AR, MS, JvS, AVS, NV, HRW, SW, CPN. In vitro/in vivo data acquisition and analysis: TJM, NTK, GCG, XL, CG. Genetic data acquisition: ARIC: AA, ML, EZS, LRGP: MLB, Lifelines: RAdB, PvdM, Bright: AFD, RS-I: ME, MGH-CAMP: PE, PLH, ZX, MESA: XG, SHIP: SBF, UV, HV, AGES: TBH, LJL, Generation Scotland: CH, CHS: SRH, BMP, KMR, JIR, NEO: JWJ, ST, YFS: MK, OTR, ERF: JAK, INTER99: AL, OP, WHI: MP, KORA: AP, MFS, KS, MW, Korcula: OP, RS-I: AU, LRGP: IV, JHS: JGW. Replication study: UKBB: IN, SV-D, MO, JR, PDL, AT, PBM; deCODE: GS, DOA, UT, DFG, KS, HH. Data interpretation and cohort oversight: LRGP: FWA, SHIP: MD, ERF: CMvD, INGI-CARL: PG AGES: VG, INTER99: TH, JKK, KORA: SK, WHI: CK, YFS: TL, MESA: HJL, MGH-CAMP: SAL, NEO: DOM-K, FHS: CHN-C, GOCHA: JR, Korcula: IR, GRAPHIC: NJS, INGI-CARL: GS, Generation Scotland: BHS, RS-I: BHS, INGI-FVG: SU, UHP: FWA, BRIGHT: PBM, CHS: NS, ARIC: DEA, TwinsUK: TDS, YJ, In vitro studies: TJM, SSA, In vivo studies: TJM, SSA, CWL.