Table 1 Lead SNPs for 28 loci identified for QRS duration in a combined European and African American ancestry meta-analysis
From: Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Locus | Band | dbSNPID | A1/A2 | cMAF | beta(se) | P | n | Nearest gene | Annotation |
|---|---|---|---|---|---|---|---|---|---|
Novel loci | |||||||||
1 | 2q31.2 | rs17362588 | A/G | 0.081 | 0.52 (0.08) | 4.20 × 10−11 | 85,593 | CCDC141 | Non-synonymous |
2 | 3p22.2 | rs116202356 | A/G | 0.015 | − 1.63 (0.17) | 1.23 × 10−20 | 85,593 | DLEC1 | Non-synonymous |
3 | 3q27.2 | rs6762208 | A/C | 0.357 | − 0.31 (0.05) | 3.45 × 10−12 | 85,593 | SENP2 | Non-synonymous |
4 | 6q22.32 | rs4549631 | C/T | 0.481 | 0.28 (0.04) | 5.56 × 10−11 | 85,593 | PRELID1P1 | Intergenic |
5 | 8q24.13 | rs16898691 | G/C | 0.040 | − 0.92 (0.11) | 5.71 × 10−16 | 79,976 | KLHL38 | Non-synonymous |
6 | 12q13.3 | rs2926743 | A/G | 0.257 | − 0.32 (0.05) | 9.40 × 10−11 | 85,593 | NACA | Non-synonymous |
7 | 15q26.3 | rs4966020 | G/A | 0.387 | − 0.27 (0.04) | 2.99 × 10−9 | 85,593 | IGF1R | Intronic |
8 | 20p12.3 | rs961253 | A/C | 0.357 | 0.30 (0.04) | 1.20 × 10−11 | 85,593 | CASC20 | Intergenic |
Previously identified loci | |||||||||
9 | 1p32.3 | rs11588271 | A/G | 0.333 | − 0.34 (0.05) | 7.59 × 10−14 | 85,593 | CDKN2C | Intergenic |
10 | 1p13.1 | rs4074536 | C/T | 0.305 | − 0.29 (0.05) | 8.27 × 10−10 | 85,593 | CASQ2 | Non-synonymous |
11 | 2p22.2 | rs7562790 | G/T | 0.424 | 0.37 (0.04) | 4.34 × 10−17 | 85,593 | CRIM1 | Intronic |
12 | 2p22.2 | rs17020136 | C/T | 0.185 | 0.38 (0.07) | 1.02 × 10−8 | 59,876 | HEATR5B | Intronic |
13 | 3p22.2 | rs6795970 | A/G | 0.371 | 0.80 (0.05) | 9.19 × 10−70 | 85,593 | SCN10A | Non-synonymous |
14 | 3p21.1 | rs4687718 | A/G | 0.164 | − 0.36 (0.06) | 1.19 × 10−8 | 83,134 | TKT | Intronic |
15 | 5q33.2 | rs13165478 | A/G | 0.377 | − 0.68 (0.04) | 6.74 × 10−52 | 85,593 | HAND1 | Intergenic |
16 | 6p21.2 | rs9470361 | A/G | 0.249 | 0.84 (0.05) | 1.21 × 10−63 | 85,593 | CDKN1A | Intergenic |
17 | 6q22.31 | rs11153730 | C/T | 0.475 | 0.56 (0.04) | 1.99 × 10−38 | 85,593 | SLC35F1 | Intergenic |
18 | 7p14.2 | rs1362212 | A/G | 0.144 | 0.55 (0.06) | 1.22 × 10−18 | 85,593 | TBX20 | Intergenic |
19 | 7p12.3 | rs7784776 | G/A | 0.397 | 0.27 (0.04) | 1.18 × 10−9 | 85,593 | IGFBP3 | Intergenic |
20 | 7q31.2 | rs3807989 | A/G | 0.427 | 0.40 (0.04) | 2.14 × 10−19 | 85,593 | CAV1 | Intronic |
21 | 12q24.21 | rs3825214 | G/A | 0.200 | 0.46 (0.05) | 1.10 × 10−17 | 85,593 | TBX5 | Intronic |
22 | 12q24.21 | rs7966651 | T/C | 0.270 | − 0.38 (0.05) | 6.74 × 10−15 | 85,593 | TBX3 | Intergenic |
23 | 13q22.1 | rs1886512 | A/T | 0.380 | − 0.36 (0.05) | 3.17 × 10−13 | 70,887 | KLF12 | Intronic |
24 | 14q24.2 | rs11848785 | G/A | 0.237 | − 0.44 (0.05) | 5.59 × 10−18 | 85,593 | SIPA1L1 | Intronic |
25 | 17q21.32 | rs17608766 | C/T | 0.127 | 0.70 (0.07) | 9.81 × 10−27 | 85,593 | GOSR2 | UTR3 |
26 | 17q24.2 | rs9912468 | G/C | 0.416 | 0.43 (0.05) | 2.34 × 10−21 | 79,976 | PRKCA | Intronic |
27 | 18q12.3 | rs663651 | G/A | 0.446 | − 0.44 (0.05) | 6.59 × 10−18 | 61,604 | SETBP1 | Non-synonymous |
28 | 20q11.22 | rs3746435 | C/G | 0.190 | − 0.36 (0.06) | 2.67 × 10−10 | 79,976 | MYH7B | Non-synonymous |