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Table 1 Lead SNPs for 28 loci identified for QRS duration in a combined European and African American ancestry meta-analysis

From: Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Locus Band dbSNPID A1/A2 cMAF beta(se) P n Nearest gene Annotation
Novel loci
1 2q31.2 rs17362588 A/G 0.081 0.52 (0.08) 4.20 × 10−11 85,593 CCDC141 Non-synonymous
2 3p22.2 rs116202356 A/G 0.015 − 1.63 (0.17) 1.23 × 10−20 85,593 DLEC1 Non-synonymous
3 3q27.2 rs6762208 A/C 0.357 − 0.31 (0.05) 3.45 × 10−12 85,593 SENP2 Non-synonymous
4 6q22.32 rs4549631 C/T 0.481 0.28 (0.04) 5.56 × 10−11 85,593 PRELID1P1 Intergenic
5 8q24.13 rs16898691 G/C 0.040 − 0.92 (0.11) 5.71 × 10−16 79,976 KLHL38 Non-synonymous
6 12q13.3 rs2926743 A/G 0.257 − 0.32 (0.05) 9.40 × 10−11 85,593 NACA Non-synonymous
7 15q26.3 rs4966020 G/A 0.387 − 0.27 (0.04) 2.99 × 10−9 85,593 IGF1R Intronic
8 20p12.3 rs961253 A/C 0.357 0.30 (0.04) 1.20 × 10−11 85,593 CASC20 Intergenic
Previously identified loci
9 1p32.3 rs11588271 A/G 0.333 − 0.34 (0.05) 7.59 × 10−14 85,593 CDKN2C Intergenic
10 1p13.1 rs4074536 C/T 0.305 − 0.29 (0.05) 8.27 × 10−10 85,593 CASQ2 Non-synonymous
11 2p22.2 rs7562790 G/T 0.424 0.37 (0.04) 4.34 × 10−17 85,593 CRIM1 Intronic
12 2p22.2 rs17020136 C/T 0.185 0.38 (0.07) 1.02 × 10−8 59,876 HEATR5B Intronic
13 3p22.2 rs6795970 A/G 0.371 0.80 (0.05) 9.19 × 10−70 85,593 SCN10A Non-synonymous
14 3p21.1 rs4687718 A/G 0.164 − 0.36 (0.06) 1.19 × 10−8 83,134 TKT Intronic
15 5q33.2 rs13165478 A/G 0.377 − 0.68 (0.04) 6.74 × 10−52 85,593 HAND1 Intergenic
16 6p21.2 rs9470361 A/G 0.249 0.84 (0.05) 1.21 × 10−63 85,593 CDKN1A Intergenic
17 6q22.31 rs11153730 C/T 0.475 0.56 (0.04) 1.99 × 10−38 85,593 SLC35F1 Intergenic
18 7p14.2 rs1362212 A/G 0.144 0.55 (0.06) 1.22 × 10−18 85,593 TBX20 Intergenic
19 7p12.3 rs7784776 G/A 0.397 0.27 (0.04) 1.18 × 10−9 85,593 IGFBP3 Intergenic
20 7q31.2 rs3807989 A/G 0.427 0.40 (0.04) 2.14 × 10−19 85,593 CAV1 Intronic
21 12q24.21 rs3825214 G/A 0.200 0.46 (0.05) 1.10 × 10−17 85,593 TBX5 Intronic
22 12q24.21 rs7966651 T/C 0.270 − 0.38 (0.05) 6.74 × 10−15 85,593 TBX3 Intergenic
23 13q22.1 rs1886512 A/T 0.380 − 0.36 (0.05) 3.17 × 10−13 70,887 KLF12 Intronic
24 14q24.2 rs11848785 G/A 0.237 − 0.44 (0.05) 5.59 × 10−18 85,593 SIPA1L1 Intronic
25 17q21.32 rs17608766 C/T 0.127 0.70 (0.07) 9.81 × 10−27 85,593 GOSR2 UTR3
26 17q24.2 rs9912468 G/C 0.416 0.43 (0.05) 2.34 × 10−21 79,976 PRKCA Intronic
27 18q12.3 rs663651 G/A 0.446 − 0.44 (0.05) 6.59 × 10−18 61,604 SETBP1 Non-synonymous
28 20q11.22 rs3746435 C/G 0.190 − 0.36 (0.06) 2.67 × 10−10 79,976 MYH7B Non-synonymous
  1. Top panel: novel loci; bottom panel: previously identified loci
  2. Locus index number for each independent locus, Band cytogenetic band in which the lead SNP for the locus resides, dbSNPID dbSNP rs-number of the lead SNP of the locus, A1/A2 coded/non-coded alleles, cMAF cumulative minor allele frequency, beta(se) effect size (standard error) in ms, P P value, n total number of individuals analyzed for this variant, Nearest gene (nearest) gene, Annotation variant function (protein coding)