Bebbington P: The World Health Report 2001. Soc Psychiatry Psychiatr Epidemiol. 2001, 36: 473-474. 10.1007/s001270170010.
Article
PubMed
Google Scholar
Fatemi SH, Folsom TD: The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull. 2009, 35: 528-548. 10.1093/schbul/sbn187.
Article
PubMed
PubMed Central
Google Scholar
Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009, 460: 748-752.
PubMed
Google Scholar
Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kahler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PKE, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SGN, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, et al: A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014, 506: 185-190. 10.1038/nature12975.
Article
PubMed
PubMed Central
Google Scholar
Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature. 2008, 455: 237-241. 10.1038/nature07239.
Kirov G, Rujescu D, Ingason A, Collier DA, O'Donovan MC, Owen MJ: Neurexin 1 (NRXN1) deletions in schizophrenia. Schizophr Bull. 2009, 35: 851-854. 10.1093/schbul/sbp079.
Article
PubMed
PubMed Central
Google Scholar
Hill MJ, Bray NJ: Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. Am J Psychiatry. 2012, 169: 1301-1308. 10.1176/appi.ajp.2012.11121845.
Article
PubMed
Google Scholar
Cannon M, Jones PB, Murray RM: Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002, 159: 1080-1092. 10.1176/appi.ajp.159.7.1080.
Article
PubMed
Google Scholar
Brown AS, Derkits EJ: Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry. 2010, 167: 261-280. 10.1176/appi.ajp.2009.09030361.
Article
PubMed
PubMed Central
Google Scholar
Khashan AS, Abel KM, McNamee R, Pedersen MG, Webb RT, Baker PN, Kenny LC, Mortensen PB: Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry. 2008, 65: 146-152. 10.1001/archgenpsychiatry.2007.20.
Article
PubMed
Google Scholar
Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM: Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry. 1996, 53: 25-31. 10.1001/archpsyc.1996.01830010027005.
Article
PubMed
Google Scholar
Dempster E, Viana J, Pidsley R, Mill J: Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull. 2013, 39: 11-16. 10.1093/schbul/sbs139.
Article
PubMed
PubMed Central
Google Scholar
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, Murray RM, Mill J: Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet. 2011, 20: 4786-4796. 10.1093/hmg/ddr416.
Article
PubMed
PubMed Central
Google Scholar
Aberg KA, McClay JL, Nerella S, Clark S, Kumar G, Chen W, Khachane AN, Xie L, Hudson A, Gao G, Harada A, Hultman CM, Sullivan PF, Magnusson PK, van den Oord EJ: Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry. 2014, 71: 255-264. 10.1001/jamapsychiatry.2013.3730.
Article
PubMed
PubMed Central
Google Scholar
Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, Wang SC, Petronis A: Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet. 2008, 82: 696-711. 10.1016/j.ajhg.2008.01.008.
Article
PubMed
PubMed Central
Google Scholar
Pidsley R, CC YW, Volta M, Lunnon K, Mill J, Schalkwyk LC: A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics. 2013, 14: 293-10.1186/1471-2164-14-293.
Article
PubMed
PubMed Central
Google Scholar
Mill J, Heijmans BT: From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet. 2013, 14: 585-594. 10.1038/nrg3405.
Article
PubMed
Google Scholar
Jaffe AE, Irizarry RA: Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biol. 2014, 15: R31-10.1186/gb-2014-15-2-r31.
Article
PubMed
PubMed Central
Google Scholar
Guintivano J, Aryee M, Kaminsky Z: A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression. Epigenetics. 2013, 8: 290-302. 10.4161/epi.23924.
Article
PubMed
PubMed Central
Google Scholar
Eckhardt F, Lewin J, Cortese R, Rakyan VK, Attwood J, Burger M, Burton J, Cox TV, Davies R, Down TA, Haefliger C, Horton R, Howe K, Jackson DK, Kunde J, Koenig C, Liddle J, Niblett D, Otto T, Pettett R, Seemann S, Thompson C, West T, Rogers J, Olek A, Berlin K, Beck S: DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet. 2006, 38: 1378-1385. 10.1038/ng1909.
Article
PubMed
PubMed Central
Google Scholar
Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM: Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol. 2009, 27: 361-368. 10.1038/nbt.1533.
Article
PubMed
PubMed Central
Google Scholar
Wang D, Yan L, Hu Q, Sucheston LE, Higgins MJ, Ambrosone CB, Johnson CS, Smiraglia DJ, Liu S: IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data. Bioinformatics. 2012, 28: 729-730. 10.1093/bioinformatics/bts013.
Article
PubMed
PubMed Central
Google Scholar
Fujino T, Leslie JH, Eavri R, Chen JL, Lin WC, Flanders GH, Borok E, Horvath TL, Nedivi E: CPG15 regulates synapse stability in the developing and adult brain. Genes Dev. 2011, 25: 2674-2685. 10.1101/gad.176172.111.
Article
PubMed
PubMed Central
Google Scholar
Chandler D, Dragovic M, Cooper M, Badcock JC, Mullin BH, Faulkner D, Wilson SG, Hallmayer J, Howell S, Rock D, Palmer LJ, Kalaydjieva L, Jablensky A: Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010, 153B: 428-437.
PubMed
Google Scholar
Zhang B, Horvath S: A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol. 2005, 4: Article17-
PubMed
Google Scholar
Langfelder P, Horvath S: WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008, 9: 559-10.1186/1471-2105-9-559.
Article
PubMed
PubMed Central
Google Scholar
Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014, 511: 421-427. 10.1038/nature13595.
Hosack DA, Dennis G, Sherman BT, Lane HC, Lempicki RA: Identifying biological themes within lists of genes with EASE. Genome Biol. 2003, 4: R70-10.1186/gb-2003-4-10-r70.
Article
PubMed
PubMed Central
Google Scholar
Guilmatre A, Huguet G, Delorme R, Bourgeron T: The emerging role of SHANK genes in neuropsychiatric disorders. Dev Neurobiol. 2014, 74: 113-122. 10.1002/dneu.22128.
Article
PubMed
Google Scholar
Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, Ding S: Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell. 2011, 9: 113-118. 10.1016/j.stem.2011.07.002.
Article
PubMed
PubMed Central
Google Scholar
The Douglas-Bell Canada Brain Bank. [], [http://douglasbrainbank.ca/]
Thibaut F: Why schizophrenia genetics needs epigenetics: a review. Psychiatr Danub. 2012, 24: 25-27.
PubMed
Google Scholar
Spadaro PA, Bredy TW: Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Front Genet. 2012, 3: 132-10.3389/fgene.2012.00132.
Article
PubMed
PubMed Central
Google Scholar
McGirr A, Tousignant M, Routhier D, Pouliot L, Chawky N, Margolese HC, Turecki G: Risk factors for completed suicide in schizophrenia and other chronic psychotic disorders: a case-control study. Schizophr Res. 2006, 84: 132-143. 10.1016/j.schres.2006.02.025.
Article
PubMed
Google Scholar
Team RDC: In R: A Language and Environment for Statistical Computing. Edited by Computing RFfS. 2005.
Hansen KD, Aryee M: minfi: Analyze Illumina’s 450k methylation arrays. R package version 1.2.0. 2012, [], [http://bioconductor.org/packages/release/bioc/html/minfi.html]
Davis S, Du P, Bilke S, Triche T, Bootwalla M: Methylumi: handle illumina methylation data, R package. 2012, [], [http://www.bioconductor.org/packages/release/bioc/html/methylumi.html]
Viana J, Pidsley R, Troakes C, Spiers H, Wong CC, Al-Sarraj S, Craig I, Schalkwyk L, Mill J: Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47, XXY) karyotype in the brain. Epigenetics. 2014, 9: 587-599. 10.4161/epi.27806.
Article
PubMed
PubMed Central
Google Scholar
Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, Al-Sarraj S, Dobson R, Schalkwyk LC, Mill J: Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 2012, 13: R43-10.1186/gb-2012-13-6-r43.
Article
PubMed
PubMed Central
Google Scholar
Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW, Gallinger S, Hudson TJ, Weksberg R: Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics. 2013, 8: 203-209. 10.4161/epi.23470.
Article
PubMed
PubMed Central
Google Scholar
Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004, 3: Article3-
PubMed
Google Scholar
Zhang H, Meltzer P, Davis S: RCircos: an R package for Circos 2D track plots. BMC Bioinformatics. 2013, 14: 244-10.1186/1471-2105-14-244.
Article
PubMed
PubMed Central
Google Scholar
Florian Hahne SD, Robert I, Arne M, Steve L, Ge T: Gviz: Plotting data and annotation information along genomic coordinates, R package version 1.6.0. 2014, [], [http://www.bioconductor.org/packages/release/bioc/html/Gviz.html]
Ingenuity Pathway Analysis. 2014, [], [http://www.ingenuity.com/]
DAVID Bioinformatics Resources. 2014, [], [http://david.abcc.ncifcrf.gov]