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We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein m...
As more complete genomes are sequenced, conservation of gene order between different organisms is emerging as an informative property of the genomes. Conservation of gene order has been used for predicting fun...
In global gene expression profiling experiments, variation in the expression of genes of interest can often be hidden by general noise. To determine how biologically significant variation can be distinguished ...
The mammalian olfactory apparatus is able to recognize and distinguish thousands of structurally diverse volatile chemicals. This chemosensory function is mediated by a very large family of seven-transmembrane...
A report on the 'Cell and Tissue Morphogenesis' Spring Meeting of the British Societies for Cell and Developmental Biology, University of Sussex, Brighton, UK, 3-6 April, 2001.
A report on the Keystone Symposium on 'Human Genetics and Genomics', Breckenridge, Colorado, USA, 31 March to 6 April, 2001.
A library of random protein sequences has yielded novel, ATP-binding proteins not found in any organism.
Information for establishing the anterior-posterior axis of a mammalian embryo is contained in the fertilized egg.
Fanconi anemia and breast cancer have been shown to share a common DNA repair pathway.
Comparison of the two drafts of the human genome sequence has revealed reassuring similarity but also some differences.
The Blocks server allows access to multiply aligned ungapped sequence segments corresponding to the most highly conserved regions of proteins, and aids detection and verification of protein sequence homologies...
The proper balance between epithelial cell proliferation, quiescence, and apoptosis during development is mediated by the specific temporal and spatial appearance of transcription factors, growth factors, cyto...
A report on the Association of Biomolecular Resource Facilities (ABRF) meeting, San Diego, USA, 24-27 February, 2001.
A report on the third Microarray Gene Expression Database group meeting (MGED3), Stanford University, Palo Alto, California, USA, 29-31 March, 2001.
Germ-cell nuclear factor (GCNF, NR6AI) is an orphan nuclear receptor. Its expression pattern suggests it functions during embryogenesis, in the placenta and in germ-cell development. Mouse GCNF cDNA codes for a p...
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