Open Access

Erratum to: The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas

  • Giulia Saraconi1,
  • Francesco Severi1,
  • Cesare Sala1,
  • Giorgio Mattiuz1 and
  • Silvestro G Conticello1Email author
Genome Biology201415:497

https://doi.org/10.1186/s13059-014-0497-9

Received: 15 September 2014

Published: 8 November 2014

The original article was published in Genome Biology 2014 15:417

Abstract

No abstract

Erratum

During the typesetting of the final version of the article [1] some data in Table 1 have been accidentally changed. These data were correct in the provisional version of the article. A correct Table 1 is as follows:
Table 1

List of the non-clonal mutations identified in the BCR-ABL1 fusion gene from imatinib-resistant K562 clones

Samples

Position

AA change

Codon change

Sequence context

Control

1409

E495G

GAA?>?GGA

 

1472

R491Q

CGG?>?CAG

GCCGG

1503

Silent

TTT?>?TTC

 

AID

298

G100C

GGC?>?TGC

GCCTA

395

Silent

AAA?>?AAG

 

568

G190D

GGC?>?GAC

TGCCA

633

T212A

ACG?>?GCG

 

Rat APOBEC1

344

G155D

GGC?>?GAC

GGCCA

607

L203M

CTG?>?ATG

CCCTG

613

E205K

GAG?>?AAG

CTCGG

764

K255T

AAG?>?ACG

 

987

Silent

GGG?>?GGT

TTCCC

Human APOBEC1

669

Silent

AGC?>?AGT

AGCCG

758

R253H

CGC?>?CAC

TGCGC

841*

Silent

CTG?>?TTG

AGCTG

697

H233D

CAT?>?GAT

TTCAT

699

H233D

CAT?>?GAC

 

1149*

Silent

GCC?>?GCA

GCCAT

1245*

F415L

TTT?>?TTG

 

The region analyzed (encompassing exon 13 of BCR and exon 9 of ABL1) includes the imatinib-binding region of the fusion gene. The asterisk indicates mutations found in the same clone. The local sequence context for the mutations at cytosines is shown. Compared to the AID-induced mutations found in previous reports (mutations in approximately 30% of the sequences) [41], [42], we found approximately one mutation in each of the clones analyzed. This is explained by the different procedures we used to select resistant clones: whereas the other studies focused on competing bulk populations of AID-transfected GFP(+) cells and control GFP(?) cells, we analyzed individual clones arising from the same number of cells plated in the presence of imatinib.

Please note that references 41 and 42 in the table legend correspond to the reference order in the original article [1].

Notes

Authors’ Affiliations

(1)
Core Research Laboratory, Istituto Toscano Tumori

References

  1. Saraconi G, Severi F, Sala C, Mattiuz G, Conticello SG: The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas. Genome Biology. 2014, 15: 417-10.1186/s13059-014-0417-z.PubMedPubMed CentralView ArticleGoogle Scholar

Copyright

© Saraconi et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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