Erratum to: The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas

Table 1 List of the non-clonal mutations identified in the BCR-ABL1 fusion gene from imatinib-resistant K562 clones

Samples	Position	AA change	Codon change	Sequence context
Control	1409	E495G	GAA?>?GGA
	1472	R491Q	CGG?>?CAG	GCCGG
	1503	Silent	TTT?>?TTC
AID	298	G100C	GGC?>?TGC	GCCTA
	395	Silent	AAA?>?AAG
	568	G190D	GGC?>?GAC	TGCCA
	633	T212A	ACG?>?GCG
Rat APOBEC1	344	G155D	GGC?>?GAC	GGCCA
	607	L203M	CTG?>?ATG	CCCTG
	613	E205K	GAG?>?AAG	CTCGG
	764	K255T	AAG?>?ACG
	987	Silent	GGG?>?GGT	TTCCC
Human APOBEC1	669	Silent	AGC?>?AGT	AGCCG
	758	R253H	CGC?>?CAC	TGCGC
	841*	Silent	CTG?>?TTG	AGCTG
	697	H233D	CAT?>?GAT	TTCAT
	699	H233D	CAT?>?GAC
	1149*	Silent	GCC?>?GCA	GCCAT
	1245*	F415L	TTT?>?TTG

The region analyzed (encompassing exon 13 of BCR and exon 9 of ABL1) includes the imatinib-binding region of the fusion gene. The asterisk indicates mutations found in the same clone. The local sequence context for the mutations at cytosines is shown. Compared to the AID-induced mutations found in previous reports (mutations in approximately 30% of the sequences) [41], [42], we found approximately one mutation in each of the clones analyzed. This is explained by the different procedures we used to select resistant clones: whereas the other studies focused on competing bulk populations of AID-transfected GFP(+) cells and control GFP(?) cells, we analyzed individual clones arising from the same number of cells plated in the presence of imatinib.

ISSN: 1474-760X