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Open Access

Id and aging

  • Jonathan B Weitzman
Genome Biology20012:spotlight-20010629-01

https://doi.org/10.1186/gb-spotlight-20010629-01

Published: 29 June 2001

Id1 is one of a family of helix-loop-helix (HLH) proteins that inhibits transcription by sequestering other HLH factors. It has been implicated in the regulation of cell growth and cellular aging. In the July 3 Proceedings of the National Academy of Sciences, Alani et al. provide genetic evidence supporting a role for Id1 in preventing cell aging (Proc Natl Acad Sci USA 2001, 98:7812-7816). They found that fibroblasts from Id1-null mice display premature senescence with increased expression of the cell-cycle regulators p16/INK4a, cyclin D1 and cyclin E. They show that Id1 specifically inhibits transcription of the p16/INK4a promoter, but does not affect p19/Arf regulation (although p19 is transcribed from the same locus as p16). Two E-box motifs in the p16/INK4a promoter are essential for Id1 repression. Finally, they report increased expression of p16/INK4a in vivo, in the ventral telencephalon of Id1-null embryos. The authors speculate that Id1 repression may be responsible for deregulation of p16 expression in the early stages of tumorigenesis.

References

  1. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesisGoogle Scholar
  2. Proceedings of the National Academy of Sciences , [http://www.pnas.org]
  3. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Google Scholar

Copyright

© BioMed Central Ltd 2001

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