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Celebrating 20 Years of Genome Biology

20 Years of Genome BiologyGenome Biology is celebrating its twentieth anniversary! Since launching in 2000, we've become established as the highest-ranking open access journal in our field. We're proud of our history of making cutting-edge genomics research and methods available to all.

We're looking back at our achievements and highlighting some of the most influential research published in the journal over the past two decades. We hope you join us in marking this occasion and that you consider submitting your next manuscript to Genome Biology.

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Watch: Our Journey

A Look Back at Our Milestones

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Explore major milestones from throughout Genome Biology's history.


20 Articles for 20 Years

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We’ve put together a list of twenty of our most accessed and interesting articles over the last two decades. While this list is by no means exhaustive, we hope you enjoy looking back at how far the field of genomics has come.

  1. Bulk chromatin motion has not been analyzed at high resolution. We present Hi-D, a method to quantitatively map dynamics of chromatin and abundant nuclear proteins for every pixel simultaneously over the entir...

    Authors: Haitham A. Shaban, Roman Barth, Ludmila Recoules and Kerstin Bystricky
    Citation: Genome Biology 2020 21:95
  2. Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized.

    Authors: Pablo E. García-Nieto, Ashby J. Morrison and Hunter B. Fraser
    Citation: Genome Biology 2019 20:298
  3. Scanpy is a scalable toolkit for analyzing single-cell gene expression data. It includes methods for preprocessing, visualization, clustering, pseudotime and trajectory inference, differential expression testing,...

    Authors: F. Alexander Wolf, Philipp Angerer and Fabian J. Theis
    Citation: Genome Biology 2018 19:15
  4. Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and comprise over 90% of mouse models created. Condit...

    Authors: Rolen M. Quadros, Hiromi Miura, Donald W. Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P. Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M. Buckley, Parthasarathy Seshacharyulu, Surinder K. Batra, Mark A. Behlke, Sarah A. Zeiner, Ashley M. Jacobi…
    Citation: Genome Biology 2017 18:92

    The Perspective to this article has been published in Nature Protocols 2022 17:s41596-022-00721-7

    The Related Article to this article has been published in Nature Protocols 2017 13:nprot.2017.153

  5. RNA-sequencing (RNA-seq) has a wide variety of applications, but no single analysis pipeline can be used in all cases. We review all of the major steps in RNA-seq data analysis, including experimental design, ...

    Authors: Ana Conesa, Pedro Madrigal, Sonia Tarazona, David Gomez-Cabrero, Alejandra Cervera, Andrew McPherson, Michał Wojciech Szcześniak, Daniel J. Gaffney, Laura L. Elo, Xuegong Zhang and Ali Mortazavi
    Citation: Genome Biology 2016 17:13

    The Erratum to this article has been published in Genome Biology 2016 17:181

  6. DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biolo...

    Authors: Riccardo E Marioni, Sonia Shah, Allan F McRae, Brian H Chen, Elena Colicino, Sarah E Harris, Jude Gibson, Anjali K Henders, Paul Redmond, Simon R Cox, Alison Pattie, Janie Corley, Lee Murphy, Nicholas G Martin, Grant W Montgomery, Andrew P Feinberg…
    Citation: Genome Biology 2015 16:25
  7. Recent data from genome-wide chromosome conformation capture analysis indicate that the human genome is divided into conserved megabase-sized self-interacting regions called topological domains. These topologi...

    Authors: Jonas Ibn-Salem, Sebastian Köhler, Michael I Love, Ho-Ryun Chung, Ni Huang, Matthew E Hurles, Melissa Haendel, Nicole L Washington, Damian Smedley, Christopher J Mungall, Suzanna E Lewis, Claus-Eric Ott, Sebastian Bauer, Paul N Schofield, Stefan Mundlos, Malte Spielmann…
    Citation: Genome Biology 2014 15:423
  8. TopHat is a popular spliced aligner for RNA-sequence (RNA-seq) experiments. In this paper, we describe TopHat2, which incorporates many significant enhancements to TopHat. TopHat2 can align reads of various le...

    Authors: Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley and Steven L Salzberg
    Citation: Genome Biology 2013 14:R36
  9. Cannabis sativa has been cultivated throughout human history as a source of fiber, oil and food, and for its medicinal and intoxicating properties. Selective breeding has produced cannabis plants for specific use...

    Authors: Harm van Bakel, Jake M Stout, Atina G Cote, Carling M Tallon, Andrew G Sharpe, Timothy R Hughes and Jonathan E Page
    Citation: Genome Biology 2011 12:R102
  10. We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced...

    Authors: Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily SW Wong, Christophe M Lefèvre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger…
    Citation: Genome Biology 2011 12:R81

    The Erratum to this article has been published in Genome Biology 2011 12:414

  11. High-throughput sequencing assays such as RNA-Seq, ChIP-Seq or barcode counting provide quantitative readouts in the form of count data. To infer differential signal in such data correctly and with good statis...

    Authors: Simon Anders and Wolfgang Huber
    Citation: Genome Biology 2010 11:R106
  12. The genome of the domestic cow, Bos taurus, was sequenced using a mixture of hierarchical and whole-genome shotgun sequencing methods.

    Authors: Aleksey V Zimin, Arthur L Delcher, Liliana Florea, David R Kelley, Michael C Schatz, Daniela Puiu, Finnian Hanrahan, Geo Pertea, Curtis P Van Tassell, Tad S Sonstegard, Guillaume Marçais, Michael Roberts, Poorani Subramanian, James A Yorke and Steven L Salzberg
    Citation: Genome Biology 2009 10:R42
  13. We present Model-based Analysis of ChIP-Seq data, MACS, which analyzes data generated by short read sequencers such as Solexa's Genome Analyzer. MACS empirically models the shift size of ChIP-Seq tags, and use...

    Authors: Yong Zhang, Tao Liu, Clifford A Meyer, Jérôme Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li and X Shirley Liu
    Citation: Genome Biology 2008 9:R137

    The Related Article to this article has been published in Nature Protocols 2012 7:nprot.2012.101

  14. The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative developme...

    Authors: Robert C Gentleman, Vincent J Carey, Douglas M Bates, Ben Bolstad, Marcel Dettling, Sandrine Dudoit, Byron Ellis, Laurent Gautier, Yongchao Ge, Jeff Gentry, Kurt Hornik, Torsten Hothorn, Wolfgang Huber, Stefano Iacus, Rafael Irizarry, Friedrich Leisch…
    Citation: Genome Biology 2004 5:R80
  15. The recent discoveries of microRNA (miRNA) genes and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have set the stage for elucidation of ...

    Authors: Anton J Enright, Bino John, Ulrike Gaul, Thomas Tuschl, Chris Sander and Debora S Marks
    Citation: Genome Biology 2003 5:R1
  16. The distributed nature of biological knowledge poses a major challenge to the interpretation of genome-scale datasets, including those derived from microarray and proteomic studies. This report describes DAVID...

    Authors: Glynn Dennis Jr, Brad T Sherman, Douglas A Hosack, Jun Yang, Wei Gao, H Clifford Lane and Richard A Lempicki
    Citation: Genome Biology 2003 4:R60
  17. Gene-expression analysis is increasingly important in biological research, with real-time reverse transcription PCR (RT-PCR) becoming the method of choice for high-throughput and accurate expression profiling ...

    Authors: Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe and Frank Speleman
    Citation: Genome Biology 2002 3:research0034.1

Annual Journal Metrics

  • 2022 Citation Impact
    12.3 - 2-year Impact Factor
    17.4 - 5-year Impact Factor
    3.476 - SNIP (Source Normalized Impact per Paper)
    9.249 - SJR (SCImago Journal Rank)

    2023 Speed
    21 days submission to first editorial decision for all manuscripts (Median)
    277 days submission to accept (Median)

    2023 Usage 
    12,515 Altmetric mentions

Peer Review Taxonomy

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  • Identity transparency: Single anonymized
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