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Table 1 Fisher’s exact test p values about the enrichment of T2D- and CRC-related functional terms in the DA taxa found by DESeq2-phyloseq or mbImpute-empowered DESeq2-phyloseq

From: mbImpute: an accurate and robust imputation method for microbiome data

DA method T2D term 1* T2D term 2** CRC term***
DESeq2-phyloseq 0.54 0.76 0.0027
mbImpute-empowered DESeq2-phyloseq 0.03 0.17 0.0010
  1. For each term, the DA taxa identified by each method from the corresponding datasets are pooled to do the test.
  2. *T2D term 1: “The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).”
  3. **T2D term 2: “A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.”
  4. ***CRC term: “Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI”