mbImpute: an accurate and robust imputation method for microbiome data

Table 1 Fisher’s exact test p values about the enrichment of T2D- and CRC-related functional terms in the DA taxa found by DESeq2-phyloseq or mbImpute-empowered DESeq2-phyloseq

DA method	T2D term 1*	T2D term 2**	CRC term***
DESeq2-phyloseq	0.54	0.76	0.0027
mbImpute-empowered DESeq2-phyloseq	0.03	0.17	0.0010

For each term, the DA taxa identified by each method from the corresponding datasets are pooled to do the test.
^*T2D term 1: “The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).”
^**T2D term 2: “A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.”
^***CRC term: “Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI”

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