Fig. 2

Hierarchical clustering of the top 2500 most variable exons in TCGA breast normal. Unsupervised hierarchical clustering of mean-centered coverage of the 2500 exons with the highest variability across the 989 TCGA normals. Color bars indicate protocol differences (black = Agilent, white = Nimblegen v 2.0, red = Nimblegen v 3.0) and analyte type (gray = whole genome amplification, white = DNA). Groups defined by hclust are identified by color in the bottom row