Fig. 1

Comparison of methylation aging in mice and human livers. a Mapping from mouse CpG sites profiled by reduced representation bisulfite sequencing (RRBS) to orthologous CpG sites profiled by Illumina 450 K human methylation array. Detailed procedures can be found in “Methods.” The Venn diagram describes the age-associated sites in the orthologous–profiled space. b, c Entropy across all age-associated sites in mouse (b) and in humans (c) is plotted over age. Pearson’s correlation (r) is displayed (mouse p < 10⁻¹¹, human p < 10⁻¹¹). FDR false discovery rate