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Table 1 Summary of major candidate regions identified from XP-EHH and XP-CLR in each breed comparison (see Additional files 2 and 3 for summary values of all candidate genes)

From: The genome landscape of indigenous African cattle

Gene

CHRa

Max XP-EHHb

XP-EHH P valuec

XP-CLR

Association

Candidate SNP position

Selected breed

HCRTR1

2

-

-

597.3

Circadian rhythm, feeding behavior

 

N’Dama

STOM

8

-

-

525.0

Anemia

112665146

(p.Met48Val)

N’Dama

SLC40A1

2

3.32

0.0002

831.1

Anemia

-

N’Dama

SBDS

25

2.91

0.0024

-

Anemia

-

N’Dama

EPB42

10

-

-

511.1

Anemia

38523031

(p.Arg503His)

N’Dama

RPS26

6

-

-

562.8

Anemia

-

N’Dama

KIT

6

1.80

0.0050

-

Coat color

-

Ankole

MITF

22

1.90

0.0032

-

Coat color

-

Ankole

PDGFRA

6

2.56

0.0001

319.3

Coat color

-

Ankole

FGF18

20

-

-

182.3

Horn development

-

Ankole

MC1R

18

-

-

295.0

Coat color

 

Ankole

SOD1

1

-

-

333.31

Thermoregulation

3116044

(p.Ile95Phe)

B. indicus

-

-

186.33

African

PRLH

3

1.49

0.0014

-

Thermoregulation

117646610

(p.Arg76His)

B. indicus

1.17

0.0039

-

African

BOLA

23

1.19

0.003

110.13

Tick resistance

-

African

  1. Dash (–) indicates non-significant results
  2. aChromosome
  3. bMaximum (positive) XP-EHH score of all SNPs within a window
  4. cRank-based empirical P value of genomic region