Open Access

Erratum to: Promoter-like epigenetic signatures in exons displaying cell type-specific splicing

  • Joao Curado1, 2,
  • Camilla Iannone1, 3,
  • Hagen Tilgner1, 4,
  • Juan Valcárcel1, 3, 5 and
  • Roderic Guigó1, 3Email author
Contributed equally
Genome Biology201617:52

https://doi.org/10.1186/s13059-016-0890-7

Received: 29 January 2016

Accepted: 29 January 2016

Published: 18 March 2016

The original article was published in Genome Biology 2015 16:236

After the publication of this work [1] an error was noticed in Fig. 7. The panel ‘h’ is missing from Fig. 7. Please see the corrected figure below. The publisher apologises for this error.
Fig. 7

Relationship between promoter and ‘promoter-like’ exons. a Distribution of the distance (in nucleotides) between annotated TSS of ‘promoter-like’ and non-‘promoter-like’ exons. b Distribution of the distance (in nucleotides) between ‘promoter-like’ exons and the nearest active TSS in C-higher and C-lower cell lines. c Proportion of ‘promoter-like’ exons in which the active TSS is closer in C-higher than in C-lower cell lines, in C-lower than in C-higher cell lines, and at the same distance in C-higher and C-lower cell lines. The total number of exons displaying differences in TSS usage is 51. d USCS Genome browser view of the DENND3 gene, that contains a ‘promoter-like’ exon (in red) more included in Hela (0.91) than in Gm12878 cells (0.75). Genomic tracks for CAGE, DNase I, and ChIPSeq of H3K9ac, H3K27ac, andH3K4me3 levels are displayed. The CAGE signal corresponding to the alternative active promoter, used in Hela, is marked with a red arrow. e ChIA-PET signal in ‘promoter-like’ exons in C-higher and C-lower cell lines. Signals are represented for regulated (AS) and flanking non-regulated (notAS) exons. Significance levels are indicated by * (0.05 > P > 0.01), ** (0.01 > P > 0.001), *** (0.001 > P), and ns (P > 0.05). f ChIA-PET in ‘promoter-like’ exons separated in bins according to their distance to the TSS. Significance levels are indicated by * (0.05 > P > 0.01), ** (0.01 > P > 0.001), *** (0.001 > P), and ns (P > 0.05). g USCS Genome browser view of the P4HA1 gene, that contains an exon (in red) more included in Hela (0.34) than in K562 (0.21) cells. Genomic tracks for DNase I, ChIA-PET, and ChIPSeq of Pol II, H3K9ac, H3K27ac, and H3K4me3 are displayed. The ChIA-PET signal, specific of Hela cells, is marked with a blue arrow. h H3K4me3, H3K9ac, and H3K27ac levels on ‘promoter-like’ exons and at the corresponding closest active TSS. The fold-change between the ChIPSeq signal in C-higher and C-lower is significantly higher (P value <2.2e-7) in the exon than in the TSS for all histone modifications considered

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
(2)
Graduate program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto
(3)
Universitat Pompeu Fabra
(4)
Department of Genetics, Stanford University
(5)
Institució Catalana de Recerca i Estudis Avançats

References

  1. Curado J, Iannone C, Tilgner H, Valcárcel J, Guigó R. Promoter-like epigenetic signatures in exons displaying cell type-specific splicing. Genome Biol. 2015;16:236.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© Curado et al. 2016

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