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Figure 3 | Genome Biology

Figure 3

From: Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome

Figure 3

CIRS-seq data allow correct inference of native deproteinized RNA secondary structures. (a) Normalized reactivity profiles for the U2 snRNA and overlay of reactivity data on the secondary structure inferred from chemical constraints. Bases are color coded according to their reactivity. The structure of the human ortholog with superimposed SHAPE-reactive positions from [57], and the unconstrained MFE structure are also shown. (b) Normalized reactivity profiles for the low-abundance U12 snRNA and overlay of reactivity data on the secondary structure inferred from chemical constraints. Bases are color coded according to their reactivity. The structure of the U12 A. thaliana ortholog with superimposed DMS/SHAPE-reactive positions from [58], and the unconstrained MFE structure are also shown.

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Genome Biology

ISSN: 1474-760X

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