Figure 2

Glucocorticoid regulation occurs with gene-specific utilization of GR functional surfaces. U2OS cells expressing GR alleles were treated for 4 h with dexamethasone or vehicle (ethanol). Scatterplots of expression changes (log2-fold change) at 4 h are shown with the GRα response (log2-fold change) on the x-axis and the response for another allele on the y-axis: A477T, GRγ, 30iiB, or E773R. Only genes with significant (adjusted P <0.05) changes in expression are shown, as open circles: those with changes that were significant in GRα are pink, significant in the other allele are green and significant in both are orange.