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Myc targets

There is intense effort to identify transcriptional targets of the c-Myc proto-oncogene that can account for its role in cell growth and division. In the January 16 Nature Gomez-Roman et al. report that c-Myc directly activates transcription by RNA polymerase III (pol III) (Nature 2003, 421:290-294). Analysis of human fibroblasts and cells from c-myc knockout mice, showed that c-Myc is important for the transcription of pol-III-regulated genes, such as the B2 repetitive gene family, 5S rRNA and tRNA genes. Chromatin immunoprecipitation experiments showed that c-Myc is associated with pol III target genes in vivo. Gomez-Roman et al. report a direct interaction between the regulatory domain of c-Myc and TFIIIB, a pol-III-specific general transcription factor. These new Myc targets help explain how c-Myc regulates growth by activating pol-II- and pol-III-dependant transcriptional programs.

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    Cell growth: downstream of Myc - to grow or to cycle?

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    Nature, [http://www.nature.com]

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Weitzman, J.B. Myc targets. Genome Biol 4, spotlight-20030120-01 (2003). https://doi.org/10.1186/gb-spotlight-20030120-01

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Keywords

  • Target Gene
  • Gene Family
  • Knockout Mouse
  • General Transcription
  • Direct Interaction