Open Access

Antibody fingerprint

  • Jonathan B Weitzman
Genome Biology20034:spotlight-20030102-01

https://doi.org/10.1186/gb-spotlight-20030102-01

Published: 2 January 2003

In an Advanced Online Publication in Nature Biotechnology, Paul Mintz and colleagues at the University of Texas M.D. Anderson Cancer Center in Texas, describe the use of phage-display technology to examine the repertoire of circulating, anti-tumour antibodies in the blood of prostate cancer patients (Nature Biotechnology, 23 December 2002, DOI:10.1038/nbt774). To characterise the 'fingerprint' of circulating antibodies they screened a phage random-peptide library with purified immunoglobulins from the serum of cancer patients and identified a number of immunoreactive peptide motifs. Reactivity correlated with disease progression and poor clinical prognosis. The anti-peptide antibodies recognise the glucose-regulated protein GRP78 which was also upregulated in metastatic prostate cancer.

References

  1. Nature Biotechnology, [http://www.nature.com/naturebiotechnology]
  2. University of Texas M.D. Anderson Cancer Center , [http://www.mdacc.tmc.edu]
  3. The glucose-regulated proteins: stress induction and clinical applications.Google Scholar

Copyright

© BioMed Central Ltd 2003

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