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Antibody fingerprint

In an Advanced Online Publication in Nature Biotechnology, Paul Mintz and colleagues at the University of Texas M.D. Anderson Cancer Center in Texas, describe the use of phage-display technology to examine the repertoire of circulating, anti-tumour antibodies in the blood of prostate cancer patients (Nature Biotechnology, 23 December 2002, DOI:10.1038/nbt774). To characterise the 'fingerprint' of circulating antibodies they screened a phage random-peptide library with purified immunoglobulins from the serum of cancer patients and identified a number of immunoreactive peptide motifs. Reactivity correlated with disease progression and poor clinical prognosis. The anti-peptide antibodies recognise the glucose-regulated protein GRP78 which was also upregulated in metastatic prostate cancer.

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    Nature Biotechnology, [http://www.nature.com/naturebiotechnology]

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    University of Texas M.D. Anderson Cancer Center , [http://www.mdacc.tmc.edu]

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    The glucose-regulated proteins: stress induction and clinical applications.

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Weitzman, J.B. Antibody fingerprint. Genome Biol 4, spotlight-20030102-01 (2003). https://doi.org/10.1186/gb-spotlight-20030102-01

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Keywords

  • Prostate Cancer
  • Prostate Cancer Patient
  • Metastatic Prostate Cancer
  • Online Publication
  • Clinical Prognosis