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Runt repression

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The transcription factor Runt can repress expression of the Drosophila segment-polarity gene engrailed (en) in the odd-numbered stripes of expression seen in the developing Drosophila embryo. In an Advanced Online Publication in Nature Genetics, Wheeler et al. describe a genetic screen for factors that potentiate Runt activity (Nature Genetics, 29 July 2002, doi:10.1038/ng942). They identified genomic regions that dominantly suppress Runt-induced lethality and identified associated genes. This screen led them to four genes that encode repressors: dCtBP, Groucho, Rpd3 and tramtrack (ttk). Analysis of engrailedexpression in the different genotypes led them to a two-step model for Runt repression. Initiation of repression by Runt requires co-operation with Ttk, whereas maintenance after the blastoderm stage requires interaction with dCtBP, Groucho and Rpd3.

References

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    Mechanisms of transcriptional regulation by Runt domain proteins.

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    Nature Genetics, [http://genetics.nature.com]

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Weitzman, J.B. Runt repression. Genome Biol 3, spotlight-20020801-01 (2002) doi:10.1186/gb-spotlight-20020801-01

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Keywords

  • Transcription Factor
  • Genomic Region
  • Genetic Screen
  • Online Publication
  • Nature Genetic