Skip to main content

Advertisement

We’d like to understand how you use our websites in order to improve them. Register your interest.

Operons in worms

Operons contain multiple adjacent genes whose transcription is regulated by the transcription of a single polycistronic message. The processing of polycistronic pre-mRNA involves 3' end formation and trans-splicing by the specialized SL2 small nuclear ribonucleoprotein particle. In the June 20 Nature, Blumenthal et al. describe a screen for SL2-containing mRNAs in the Caenorhabditis elegans genome (Nature 2002, 417:851-854). They used a probe enriched for SL2-containing mRNA to hybridize to microarrays containing over 17,000 genes. They selected around 1,200 genes, including many genes with known SL2-containing mRNAs. Most of these genes (86%) are located downstream in operons, indicating a strong correlation between SL2 trans-splicing and downstream location in an operon. Blumenthal et al. estimated that the C. elegansgenome may contain as many as 1,068 operons, representing over 2,600 genes (or up to 15% of genes).

References

  1. 1.

    A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans.

  2. 2.

    Nature, [http://www.nature.com]

Download references

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weitzman, J.B. Operons in worms. Genome Biol 3, spotlight-20020620-01 (2002). https://doi.org/10.1186/gb-spotlight-20020620-01

Download citation

Keywords

  • Strong Correlation
  • Caenorhabditis Elegans
  • Adjacent Gene
  • Downstream Location
  • Ribonucleoprotein Particle