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Keeping a CHEK on breast cancer

Mutations in the tumor suppressor genes BRCA1andBRCA2 account for a small percentage of breast cancer cases. In an Advanced Online Publication from Nature Genetics, researchers from the CHEK-Breast Cancer Consortium report the identification of a mutation in the CHEK2 gene that increases the risk of breast cancer in both women and men (22 April 2002, DOI: 10.1038/ng879). They performed a genome-wide linkage search in a family with BRCA-independent breast cancer and identified a mutation in the CHEK2 gene that results in a truncated protein. CHEK2 is a cell-cycle checkpoint kinase involved in DNA-damage-response pathways. The mutation abolished kinase activity, and is five times more frequent in families affected by breast cancer who do not have BRCA1 or BRCA2 mutations.

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    Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families.

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    Nature Genetics, [http://genetics.nature.com]

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    The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

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Weitzman, J.B. Keeping a CHEK on breast cancer. Genome Biol 3, spotlight-20020424-02 (2002). https://doi.org/10.1186/gb-spotlight-20020424-02

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Keywords

  • Breast Cancer
  • Tumor Suppressor
  • Kinase Activity
  • Suppressor Gene
  • Tumor Suppressor Gene