Skip to main content

CDK7 in C. elegans

CDK7 is a kinase that is thought to play dual roles in transcription and cell-cycle regulation by phosphorylating the carboxy-terminal domain of RNA polymerase II and also phosphorylating other cyclin-dependent kinases (CDKs). In the April 16 Proceedings of the National Academy of Sciences, Wallenfang and Seydoux at the Johns Hopkins University School of Medicine describe a study of the C. elegans cdk-7 gene (Proc Natl Acad Sci USA 2002, 99:315-320). They conducted a genome-wide screen for temperature-sensitive (ts) embryonic lethal mutants affecting transcription and came up with a ts allele of cdk-7. The cdk-7 ts mutants displayed defects in mRNA synthesis and RNA polymerase phosphorylation, as well as independently regulating cell-cycle progression. They also found that cdk-7 is essential in the worm for meiosis and for maintaining normal cell ploidy.


  1. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?

  2. Proceedings of the National Academy of Sciences, []

  3. Johns Hopkins Medical Institutions , []

Download references


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weitzman, J.B. CDK7 in C. elegans. Genome Biol 3, spotlight-20020418-01 (2002).

Download citation

  • Published:

  • DOI:


  • Normal Cell
  • Dual Role
  • mRNA Synthesis
  • Lethal Mutant
  • Cell Ploidy